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A comparison between two rTMS protocols as augmentation strategies in patients with treatment-resistant depression

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العنوان: A comparison between two rTMS protocols as augmentation strategies in patients with treatment-resistant depression
المؤلفون: L. Larini, M. Castiglioni, E. Piccoli, C. Scarpa, M. Renne, S. Torriero, M. Bosi, B. Benatti, A. Varinelli, M. Vismara, B. Dell’Osso
المصدر: European Psychiatry, Vol 66, Pp S114-S115 (2023)
بيانات النشر: Cambridge University Press, 2023.
سنة النشر: 2023
المجموعة: LCC:Psychiatry
مصطلحات موضوعية: Psychiatry, RC435-571
الوصف: Introduction Repetitive transcranial magnetic stimulation (rTMS) is an evidence-based treatment and rTMS protocols have been included in international guidelines for patients with treatment-resistant depression (TRD). The daily administration of standard rTMS protocols, typically over several weeks, could be a limiting factor (e.g., time off from work, commuting issues). To intensify the antidepressant response and to reduce the number of stimulation days, it has been proposed that increasing the number of rTMS sessions performed per day could be more effective and help to reduce the burden for patients and clinicians. Although there is much interest in accelerated TMS protocols, little is known about their efficacy and tolerability, and the literature on the topic is still scarce. Objectives To compare the efficacy and tolerability of two rTMS protocols (standard vs. accelerated) as augmentative strategies in patients with TRD. Methods In the present ongoing, open-label, trial 14 patients meeting DSM-5 criteria for major depressive episode (either unipolar or bipolar), classified as partial responders or non-responders to adequate pharmacological treatment, were randomized to receive either standard (one session per day, five days a week, for four weeks; n= 7) or accelerated (two sessions per day, five days a week, for two weeks; n=6) rTMS treatment protocols. In both cases, rTMS was performed on the left dorsolateral prefrontal cortex, high frequency (10 Hz) at 120% of the motor threshold, 3000 pulses per sessions. Primary outcome measures included HAM-D, MADRS, and CGI-S scores at baseline (T0), at the end of rTMS treatment (T1), and after 1 month (T2), as well as tolerability based on adverse effects. Paired Samples t-Test for continuous variables was used to compare psychometric scales at each timepoint, while t-Test was used to compare differences between the two groups. Results With respect to total sample, in terms of primary outcome measures a significant reduction of HAM-D, MADRS and CGI-S total scores between T0 and T1 (t: 3.01, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0924-9338
1778-3585
Relation: https://www.cambridge.org/core/product/identifier/S0924933823003115/type/journal_article; https://doaj.org/toc/0924-9338; https://doaj.org/toc/1778-3585
DOI: 10.1192/j.eurpsy.2023.311
URL الوصول: https://doaj.org/article/5a4475ca0c644185b0035f0e68da8ed4
رقم الأكسشن: edsdoj.5a4475ca0c644185b0035f0e68da8ed4
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:09249338
17783585
DOI:10.1192/j.eurpsy.2023.311