دورية أكاديمية
RETRACTED ARTICLE: Topical bismuth oxide-manganese composite nanospheres alleviate atopic dermatitis-like inflammation
| العنوان: | RETRACTED ARTICLE: Topical bismuth oxide-manganese composite nanospheres alleviate atopic dermatitis-like inflammation |
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| المؤلفون: | Mengjie Li, Benjin Chen, Lingling Xu, Yu Wang, Zhu Chen, Bingyan Ma, Shichun Qin, Yechun Jiang, Cheng Gu, Haisheng Qian, Fengli Xiao |
| المصدر: | Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-16 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Atopic dermatitis, Skin inflammation, IL-4, STAT6, Bi2-xMnxO3 nanospheres, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Abstract Atopic dermatitis (AD) is a common skin disease involving important immune mechanisms. There is an unmet need for a treatment for this condition. Herein, we focused on elucidating the role of Bi2-xMnxO3 nanospheres (BM) in alleviating skin inflammation in AD-like C57BL/6 mice. The BM was fabricated via sacrificial templates and its biosafety was systematically evaluated. The BM was applied topically to skin lesions of AD-like C57BL/6 mice. The phenotypic and histological changes in the skin were examined carefully. The responses of barrier proteins, inflammatory cytokines and cells to BM were evaluated in HaCaT cells and AD mouse models. The data demonstrated that BM treatment alleviated the AD phenotypes and decreased the level of inflammatory factors, while increasing the expression of the barrier proteins filaggrin/involucrin in the skin. BM effectively reduced the expression of phosphorylated STAT6, which in turn reduced the expression of GATA3, and further decreased the differentiation ratio of Th2 cells, thereby reducing the expression of IL-4. In conclusion, topical drug therapy with BM provides a safe and effective treatment modality for AD by reducing IL-4 and increasing barrier proteins. Graphical Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1477-3155 |
| Relation: | https://doaj.org/toc/1477-3155 |
| DOI: | 10.1186/s12951-023-02207-4 |
| URL الوصول: | https://doaj.org/article/5a9d3d2b296b41649ee013a3f983ec8f |
| رقم الأكسشن: | edsdoj.5a9d3d2b296b41649ee013a3f983ec8f |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14773155 |
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| DOI: | 10.1186/s12951-023-02207-4 |