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Increased Level of Long Non-Coding RNA MALAT1 Is a Common Feature of Amoeboid Invasion

التفاصيل البيبلوغرافية
العنوان: Increased Level of Long Non-Coding RNA MALAT1 Is a Common Feature of Amoeboid Invasion
المؤلفون: Ladislav Merta, Aneta Gandalovičová, Vladimír Čermák, Michal Dibus, Tony Gutschner, Sven Diederichs, Daniel Rösel, Jan Brábek
المصدر: Cancers, Vol 12, Iss 5, p 1136 (2020)
بيانات النشر: MDPI AG, 2020.
سنة النشر: 2020
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: MALAT1, lncRNA, cancer, amoeboid invasion, mesenchymal invasion, invasion plasticity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: The ability of cancer cells to adopt various migration modes (the plasticity of cancer cell invasiveness) is a substantive obstacle in the treatment of metastasis, yet still an incompletely understood process. We performed a comparison of publicly available transcriptomic datasets from various cell types undergoing a switch between the mesenchymal and amoeboid migration modes. Strikingly, lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) was one of three genes that were found upregulated in all amoeboid cells analyzed. Accordingly, downregulation of MALAT1 in predominantly amoeboid cell lines A375m2 and A2058 resulted in decrease of active RhoA (Ras homolog family member A) and was accompanied by the amoeboid-mesenchymal transition in A375m2 cells. Moreover, MALAT1 downregulation in amoeboid cells led to increased cell proliferation. Our work is the first to address the role of MALAT1 in MAT/AMT (mesenchymal to amoeboid transition/amoeboid to mesenchymal transition) and suggests that increased MALAT1 expression is a common feature of amoeboid cells.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 12051136
2072-6694
Relation: https://www.mdpi.com/2072-6694/12/5/1136; https://doaj.org/toc/2072-6694
DOI: 10.3390/cancers12051136
URL الوصول: https://doaj.org/article/5acedc3b224b457b8ac06e2edcc94abb
رقم الأكسشن: edsdoj.5acedc3b224b457b8ac06e2edcc94abb
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:12051136
20726694
DOI:10.3390/cancers12051136