دورية أكاديمية
Increased Level of Long Non-Coding RNA MALAT1 Is a Common Feature of Amoeboid Invasion
العنوان: | Increased Level of Long Non-Coding RNA MALAT1 Is a Common Feature of Amoeboid Invasion |
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المؤلفون: | Ladislav Merta, Aneta Gandalovičová, Vladimír Čermák, Michal Dibus, Tony Gutschner, Sven Diederichs, Daniel Rösel, Jan Brábek |
المصدر: | Cancers, Vol 12, Iss 5, p 1136 (2020) |
بيانات النشر: | MDPI AG, 2020. |
سنة النشر: | 2020 |
المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
مصطلحات موضوعية: | MALAT1, lncRNA, cancer, amoeboid invasion, mesenchymal invasion, invasion plasticity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
الوصف: | The ability of cancer cells to adopt various migration modes (the plasticity of cancer cell invasiveness) is a substantive obstacle in the treatment of metastasis, yet still an incompletely understood process. We performed a comparison of publicly available transcriptomic datasets from various cell types undergoing a switch between the mesenchymal and amoeboid migration modes. Strikingly, lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) was one of three genes that were found upregulated in all amoeboid cells analyzed. Accordingly, downregulation of MALAT1 in predominantly amoeboid cell lines A375m2 and A2058 resulted in decrease of active RhoA (Ras homolog family member A) and was accompanied by the amoeboid-mesenchymal transition in A375m2 cells. Moreover, MALAT1 downregulation in amoeboid cells led to increased cell proliferation. Our work is the first to address the role of MALAT1 in MAT/AMT (mesenchymal to amoeboid transition/amoeboid to mesenchymal transition) and suggests that increased MALAT1 expression is a common feature of amoeboid cells. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 12051136 2072-6694 |
Relation: | https://www.mdpi.com/2072-6694/12/5/1136; https://doaj.org/toc/2072-6694 |
DOI: | 10.3390/cancers12051136 |
URL الوصول: | https://doaj.org/article/5acedc3b224b457b8ac06e2edcc94abb |
رقم الأكسشن: | edsdoj.5acedc3b224b457b8ac06e2edcc94abb |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 12051136 20726694 |
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DOI: | 10.3390/cancers12051136 |