دورية أكاديمية
أعرض في EDS

The role of podoplanin in the biology of differentiated thyroid cancers.

التفاصيل البيبلوغرافية
العنوان: The role of podoplanin in the biology of differentiated thyroid cancers.
المؤلفون: Magdalena Rudzińska, Damian Gaweł, Justyna Sikorska, Kamila M Karpińska, Mirosław Kiedrowski, Tomasz Stępień, Magdalena Marchlewska, Barbara Czarnocka
المصدر: PLoS ONE, Vol 9, Iss 5, p e96541 (2014)
بيانات النشر: Public Library of Science (PLoS), 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Podoplanin (PDPN), a mucin-type transmembrane glycoprotein specific to the lymphatic system is expressed in a variety of human cancers, and is regarded as a factor promoting tumor progression. The purpose of this study was to elucidate the molecular role of PDPN in the biology of thyroid cancer cells. PDPN expression was evaluated in primary thyroid carcinomas and thyroid carcinoma cell lines by RT-qPCR, Western blotting, IF and IHC. To examine the role of podoplanin in determining a cell's malignant potential (cellular migration, invasion, proliferation, adhesion, motility, apoptosis), a thyroid cancer cell line with silenced PDPN expression was used. We observed that PDPN was solely expressed in the cancer cells of 40% of papillary thyroid carcinoma (PTC) tissues. Moreover, PDPN mRNA and protein were highly expressed in PTC-derived TPC1 and BcPAP cell lines but were not detected in follicular thyroid cancer derived cell lines. PDPN knock-down significantly decreased cellular invasion, and modestly reduced cell migration, while proliferation and adhesion were not affected. Our results demonstrate that PDPN mediates the invasive properties of cells derived from papillary thyroid carcinomas, suggesting that podoplanin might promote PTC progression.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4010536?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0096541
URL الوصول: https://doaj.org/article/5ad1f4fc1d0346f48f54b6ddd56f197d
رقم الأكسشن: edsdoj.5ad1f4fc1d0346f48f54b6ddd56f197d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0096541