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Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration

التفاصيل البيبلوغرافية
العنوان: Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration
المؤلفون: Bin Yu, Ziqi Zhu, Tao Hu, Jiawei Lu, Beiduo Shen, Tongde Wu, Kai Guo, Surendra Kumar Chaudhary, Hang Feng, Weidong Zhao, Desheng Wu
المصدر: BMC Musculoskeletal Disorders, Vol 23, Iss 1, Pp 1-12 (2022)
بيانات النشر: BMC, 2022.
سنة النشر: 2022
المجموعة: LCC:Diseases of the musculoskeletal system
مصطلحات موضوعية: Intervertebral disc degeneration, Circular RNA, microRNA, mRNA, Competing endogenous RNA, Diseases of the musculoskeletal system, RC925-935
الوصف: Highlights 1. An IDD-related ceRNA network involving four circRNAs, three miRNAs and 11 mRNAs was constructed. 2. The expression levels of miR-185-5p, miR-486-5p, FOXO1, SMAD2 and TGFB1 were consistent in different databases. 3. Our study identified IDD-related circRNA–miRNA–mRNA interaction axes, including circRNA_100086–miR-509-3p–MAPK1.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1471-2474
Relation: https://doaj.org/toc/1471-2474
DOI: 10.1186/s12891-022-05579-0
URL الوصول: https://doaj.org/article/5ae2554b080241e38f92f28ece79072b
رقم الأكسشن: edsdoj.5ae2554b080241e38f92f28ece79072b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14712474
DOI:10.1186/s12891-022-05579-0