دورية أكاديمية
Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells.
| العنوان: | Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells. |
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| المؤلفون: | Joshua T Chai, Janet E Digby, Neil Ruparelia, Andrew Jefferson, Ashok Handa, Robin P Choudhury |
| المصدر: | PLoS ONE, Vol 8, Iss 5, p e62934 (2013) |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Nicotinic acid (NA) regresses atherosclerosis in human imaging studies and reduces atherosclerosis in mice, mediated by myeloid cells, independent of lipoproteins. Since GPR109A is expressed by human monocytes, we hypothesized that NA may drive cholesterol efflux from foam cells. In THP-1 cells NA suppressed LPS-induced mRNA transcription of MCP-1 by 76.6±12.2% (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3642175?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0062934 |
| URL الوصول: | https://doaj.org/article/5af487ca42814a86b9077464e9ce2543 |
| رقم الأكسشن: | edsdoj.5af487ca42814a86b9077464e9ce2543 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0062934 |