دورية أكاديمية
SCFFBXW11 Complex Targets Interleukin-17 Receptor A for Ubiquitin–Proteasome-Mediated Degradation
| العنوان: | SCFFBXW11 Complex Targets Interleukin-17 Receptor A for Ubiquitin–Proteasome-Mediated Degradation |
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| المؤلفون: | Ben Jin, Sayed Ala Moududee, Dongxia Ge, Pengbo Zhou, Alun R. Wang, Yao-Zhong Liu, Zongbing You |
| المصدر: | Biomedicines, Vol 12, Iss 4, p 755 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | FBXW11, IL-17RA, ubiquitin–proteasome-mediated degradation, Biology (General), QH301-705.5 |
| الوصف: | Interleukin-17 (IL-17) is a pro-inflammatory cytokine that participates in innate and adaptive immune responses and plays an important role in host defense, autoimmune diseases, tissue regeneration, metabolic regulation, and tumor progression. Post-translational modifications (PTMs) are crucial for protein function, stability, cellular localization, cellular transduction, and cell death. However, PTMs of IL-17 receptor A (IL-17RA) have not been investigated. Here, we show that human IL-17RA was targeted by F-box and WD repeat domain-containing 11 (FBXW11) for ubiquitination, followed by proteasome-mediated degradation. We used bioinformatics tools and biochemical techniques to determine that FBXW11 ubiquitinated IL-17RA through a lysine 27-linked polyubiquitin chain, targeting IL-17RA for proteasomal degradation. Domain 665-804 of IL-17RA was critical for interaction with FBXW11 and subsequent ubiquitination. Our study demonstrates that FBXW11 regulates IL-17 signaling pathways at the IL-17RA level. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2227-9059 49308416 |
| Relation: | https://www.mdpi.com/2227-9059/12/4/755; https://doaj.org/toc/2227-9059 |
| DOI: | 10.3390/biomedicines12040755 |
| URL الوصول: | https://doaj.org/article/5b3c04cbcd0a49308416ad0f8d2a5a20 |
| رقم الأكسشن: | edsdoj.5b3c04cbcd0a49308416ad0f8d2a5a20 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22279059 49308416 |
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| DOI: | 10.3390/biomedicines12040755 |