دورية أكاديمية
Specific functions of Exostosin-like 3 (EXTL3) gene products
| العنوان: | Specific functions of Exostosin-like 3 (EXTL3) gene products |
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| المؤلفون: | Shuhei Yamada |
| المصدر: | Cellular & Molecular Biology Letters, Vol 25, Iss 1, Pp 1-12 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | Exostosin-like 3 (EXTL3), Heparan sulfate (HS), Biosynthesis, Glycosaminoglycan, Regenerating islet-derived (REG) protein, Cytology, QH573-671 |
| الوصف: | Abstract Exostosin-like 3 (EXTL3) encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS), a sulfated polysaccharide that is ubiquitously distributed on the animal cell surface and in the extracellular matrix. A lack of EXTL3 reduces HS levels and causes embryonic lethality, indicating its indispensable role in the biosynthesis of HS. EXTL3 has also been identified as a receptor molecule for regenerating islet-derived (REG) protein ligands, which have been shown to stimulate islet β-cell growth. REG proteins also play roles in keratinocyte proliferation and/or differentiation, tissue regeneration and immune defenses in the gut as well as neurite outgrowth in the central nervous system. Compared with the established function of EXTL3 as a glycosyltransferase in HS biosynthesis, the REG-receptor function of EXTL3 is not conclusive. Genetic diseases caused by biallelic mutations in the EXTL3 gene were recently reported to result in a neuro-immuno-skeletal dysplasia syndrome. EXTL3 is a key molecule for the biosynthesis of HS and may be involved in the signal transduction of REG proteins. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1425-8153 1689-1392 |
| Relation: | http://link.springer.com/article/10.1186/s11658-020-00231-y; https://doaj.org/toc/1425-8153; https://doaj.org/toc/1689-1392 |
| DOI: | 10.1186/s11658-020-00231-y |
| URL الوصول: | https://doaj.org/article/cd5b53ba2914484797653267cfc93287 |
| رقم الأكسشن: | edsdoj.5b53ba2914484797653267cfc93287 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14258153 16891392 |
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| DOI: | 10.1186/s11658-020-00231-y |