دورية أكاديمية
A retrospective cohort study: vaccination status and safety analysis of SARS-CoV-2 vaccine in patients with Wilson’s disease
| العنوان: | A retrospective cohort study: vaccination status and safety analysis of SARS-CoV-2 vaccine in patients with Wilson’s disease |
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| المؤلفون: | Hui Han, Dan Zhao, Xinru Fang, Wenming Yang, Mengli Wang, Qianzhuo Liu, Luyao Wang, Zhihui Ji, Juan Zhang, Zhifeng Hou, Lei Hua, Yu Wang, Limin Wu |
| المصدر: | Expert Review of Vaccines, Vol 22, Iss 1, Pp 1185-1195 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Internal medicine |
| مصطلحات موضوعية: | SARS-CoV-2, vaccine, Wilson’s disease, UWDRS, COVID-19, Internal medicine, RC31-1245 |
| الوصف: | ABSTRACTBackground Wilson’s disease (WD) is a rare hepatic and neurological disorder, which can dramatically worsen by traumatic injuries, surgeries, and infections. No studies have reported safety data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in WD patients. We aimed to investigate the SARS-CoV-2 vaccination status and post-vaccination adverse events in WD patients.Methods This is a multicenter, retrospective, observational study. We investigated the vaccination rates, the type of vaccine, subjective reasons for non-vaccination, and the adverse events following vaccination. Logistic regression analysis was used to assess the correlation between vaccination status and increased Unified Wilson’s Disease Rating Scale (UWDRS) scores.Results A total of 554 WD patients with a mean (SD) age of 25.3 (10.85) years were included in this study, of whom 336 (60.6%) were males and 218 (39.4%) were females. 368 (66.4%) patients received at least one dose of the SARS-CoV-2 vaccine.186 (33.6%) patients were unvaccinated. Logistic regression analysis showed that vaccination against SARS-CoV-2 was not significantly associated with increased UWDRS scores. The safety analysis demonstrated that 21.2% had post-vaccination adverse events.Conclusions In this study, vaccination against SARS-CoV-2 was safe in WD patients, providing evidence for the safety of vaccination in WD patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 14760584 1744-8395 1476-0584 |
| Relation: | https://doaj.org/toc/1476-0584; https://doaj.org/toc/1744-8395 |
| DOI: | 10.1080/14760584.2023.2288630 |
| URL الوصول: | https://doaj.org/article/5b76d47bb8524a6295aa1b412b1cb3db |
| رقم الأكسشن: | edsdoj.5b76d47bb8524a6295aa1b412b1cb3db |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 14760584 17448395 |
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| DOI: | 10.1080/14760584.2023.2288630 |