دورية أكاديمية
Qualitative and quantitative electrocardiogram parameters in a large cohort of children with duchenne muscle dystrophy in comparison with age-matched healthy subjects: A study from South India
العنوان: | Qualitative and quantitative electrocardiogram parameters in a large cohort of children with duchenne muscle dystrophy in comparison with age-matched healthy subjects: A study from South India |
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المؤلفون: | Manu S Girija, Deepak Menon, Kiran Polavarapu, Veeramani Preethish-Kumar, Seena Vengalil, Saraswati Nashi, Madassu Keertipriya, Mainak Bardhan, Priya T Thomas, Valasani R Kiran, Vikas Nishadham, Arun Sadasivan, Akshata Huddar, Gopi K Unnikrishnan, Ganagarajan Inbaraj, Arjun Krishnamurthy, Boris W Kramer, Talakad N Sathyaprabha, Atchayaram Nalini |
المصدر: | Annals of Indian Academy of Neurology, Vol 27, Iss 1, Pp 53-57 (2024) |
بيانات النشر: | Wolters Kluwer Medknow Publications, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Neurology. Diseases of the nervous system |
مصطلحات موضوعية: | cardiac screening, duchenne muscular dystrophy, ecg, qt interval, tall r, Neurology. Diseases of the nervous system, RC346-429 |
الوصف: | Background: Electrocardiography (ECG) remains an excellent screening tool for cardiac assessment in Duchenne muscular dystrophy (DMD), but an accurate interpretation requires comparison with age-matched healthy controls. Objective: We examined various ECG parameters in children with DMD, in comparison with age-matched controls. Methods: Standard 12-lead ECG tracings of serial patients were screened for quality and selected. Controls were healthy, age-matched school-going children. Both quantitative and qualitative ECG parameters were analyzed. Results: After screening, ECGs from 252 patients with DMD (8.32 ± 3.12 years, 2–21 years) and ECGs from 151 age-matched healthy controls (9.72 ± 2.23, 4–19 years) were included. A significantly higher heart rate, shorter R–R interval, and taller R wave in V1 were seen across all age group of DMD in comparison to controls, with the difference increasing with age. While QT prolongation was seen in all age groups of DMD, QTc prolongation was seen only at 10 years or more. Incomplete right bundle branch block (RBBB) and pathological Q waves in inferolateral leads were exclusive in DMD, with the latter declining with age. Evidence for left ventricular (LV) pathology, such as tall R in V5/V6, increase in SV1 + RV6 height, and QRS complex duration, were seen only in the age group of 10 years or more. Conclusion: Stratification based on age and comparison with age-matched healthy subjects showed that several ECG parameters were influenced by age, and it also identified age-dependent evidence for LV pathology and QTc prolongation in DMD. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 0972-2327 1998-3549 |
Relation: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2024;volume=27;issue=1;spage=53;epage=57;aulast=Girija; https://doaj.org/toc/0972-2327; https://doaj.org/toc/1998-3549 |
DOI: | 10.4103/aian.aian_989_23 |
URL الوصول: | https://doaj.org/article/5b87316a68604fec83954623ac4d4310 |
رقم الأكسشن: | edsdoj.5b87316a68604fec83954623ac4d4310 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 09722327 19983549 |
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DOI: | 10.4103/aian.aian_989_23 |