دورية أكاديمية

Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder

التفاصيل البيبلوغرافية
العنوان: Insights into the structure and function of the hippocampus: implications for the pathophysiology and treatment of autism spectrum disorder
المؤلفون: Junzi Long, Hui Li, Ying Liu, Xingxing Liao, Zhiqing Tang, Kaiyue Han, Jiarou Chen, Hao Zhang
المصدر: Frontiers in Psychiatry, Vol 15 (2024)
بيانات النشر: Frontiers Media S.A., 2024.
سنة النشر: 2024
المجموعة: LCC:Psychiatry
مصطلحات موضوعية: autism spectrum disorder (ASD), hippocampus, learning, memory, cognitive map, anxiety, Psychiatry, RC435-571
الوصف: The hippocampus is one of the brain areas affected by autism spectrum disorder (ASD). Individuals with ASD typically have impairments in hippocampus-dependent learning, memory, language ability, emotional regulation, and cognitive map creation. However, the pathological changes in the hippocampus that result in these cognitive deficits in ASD are not yet fully understood. In the present review, we will first summarize the hippocampal involvement in individuals with ASD. We will then provide an overview of hippocampal structural and functional abnormalities in genetic, environment-induced, and idiopathic animal models of ASD. Finally, we will discuss some pharmacological and non-pharmacological interventions that show positive impacts on the structure and function of the hippocampus in animal models of ASD. A further comprehension of hippocampal aberrations in ASD might elucidate their influence on the manifestation of this developmental disorder and provide clues for forthcoming diagnostic and therapeutic innovation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1664-0640
Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1364858/full; https://doaj.org/toc/1664-0640
DOI: 10.3389/fpsyt.2024.1364858
URL الوصول: https://doaj.org/article/5c0cb0a55d09468da86f4a0639158139
رقم الأكسشن: edsdoj.5c0cb0a55d09468da86f4a0639158139
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16640640
DOI:10.3389/fpsyt.2024.1364858