دورية أكاديمية
Extracellular water to total body water ratio predicts survival in cancer patients with sarcopenia: a multi-center cohort study
| العنوان: | Extracellular water to total body water ratio predicts survival in cancer patients with sarcopenia: a multi-center cohort study |
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| المؤلفون: | Yi-Zhong Ge, Guo-Tian Ruan, Qi Zhang, Wen-Jun Dong, Xi Zhang, Meng-Meng Song, Xiao-Wei Zhang, Xiang-Rui Li, Kang-Ping Zhang, Meng Tang, Wei Li, Xian Shen, Han-Ping Shi, Investigation on the Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group |
| المصدر: | Nutrition & Metabolism, Vol 19, Iss 1, Pp 1-9 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Nutritional diseases. Deficiency diseases |
| مصطلحات موضوعية: | Body water, Extracellular water, Cancer sarcopenia, Bioelectrical impedance analysis, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Abstract Background Body water measured by bioelectrical impedance analysis (BIA) predicts the outcomes of many diseases. This study aimed to evaluate the relationship between body water and the prognosis of cancer patients with sarcopenia. Methods This study employed 287 cancer patients with sarcopenia underwent BIA from a prospective multicenter study of patients with cancer in China from 2013 to 2020. The primary outcome of interest was all-cause mortality presented as the longest time to follow-up available. Eight indicators of body water [total body water, extracellular water, intracellular water, free fat mass, active cell mass, extracellular water/intracellular water, extracellular water/total body water (ECW/TBW), and intracellular water/total body water] were included in the research. Neutrophil–lymphocyte ratio (NLR) = neutrophil (× 109)/lymphocyte (× 109). The discriminatory ability and prediction accuracy of each factor were assessed using the C-index. The hazard ratios (HR) and 95% confidence intervals (CI) were calculated using the Cox proportional hazard model. Results The median age was 65 years old, and 138 (48%) patients were men. During a mean follow-up of 46 months, 140 deaths were recorded, resulting in a rate of 204.6 events per 1000 patient-years. ECW/TBW showed the best predictive accuracy (C-index = 0.619) compared to the other indicators [p = 0.004, adjusted HR (95% CI) 1.70 (1.18,2.44)]. In the middle tertile (0.385–0.405), ECW/TBW had a strong independent negative association with patient survival [adjusted HR (95% CI) 2.88 (1.39–5.97), p = 0.004]. Patients who had a high ECW/TBW (ECW/TBW ≥ 0.395) combined with a high NLR had 3.84-fold risk of mortality (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1743-7075 |
| Relation: | https://doaj.org/toc/1743-7075 |
| DOI: | 10.1186/s12986-022-00667-3 |
| URL الوصول: | https://doaj.org/article/c5c2e83c8d7e40ef89caa7a2b0c3b4d0 |
| رقم الأكسشن: | edsdoj.5c2e83c8d7e40ef89caa7a2b0c3b4d0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17437075 |
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| DOI: | 10.1186/s12986-022-00667-3 |