دورية أكاديمية
Mechanical Properties and Morphological Alterations in Fiber-Based Scaffolds Affecting Tissue Engineering Outcomes
| العنوان: | Mechanical Properties and Morphological Alterations in Fiber-Based Scaffolds Affecting Tissue Engineering Outcomes |
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| المؤلفون: | James Dolgin, Samerender Nagam Hanumantharao, Stephen Farias, Carl G. Simon, Smitha Rao |
| المصدر: | Fibers, Vol 11, Iss 5, p 39 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Chemicals: Manufacture, use, etc. LCC:Textile bleaching, dyeing, printing, etc. LCC:Biology (General) LCC:Physics |
| مصطلحات موضوعية: | tissue engineering, scaffolds, mechanotransduction, biophysical cues, electrospinning, Chemicals: Manufacture, use, etc., TP200-248, Textile bleaching, dyeing, printing, etc., TP890-933, Biology (General), QH301-705.5, Physics, QC1-999 |
| الوصف: | Electrospinning is a versatile tool used to produce highly customizable nonwoven nanofiber mats of various fiber diameters, pore sizes, and alignment. It is possible to create electrospun mats from synthetic polymers, biobased polymers, and combinations thereof. The post-processing of the end products can occur in many ways, such as cross-linking, enzyme linking, and thermal curing, to achieve enhanced chemical and physical properties. Such multi-factor tunability is very promising in applications such as tissue engineering, 3D organs/organoids, and cell differentiation. While the established methods involve the use of soluble small molecules, growth factors, stereolithography, and micro-patterning, electrospinning involves an inexpensive, labor un-intensive, and highly scalable approach to using environmental cues, to promote and guide cell proliferation, migration, and differentiation. By influencing cell morphology, mechanosensing, and intracellular communication, nanofibers can affect the fate of cells in a multitude of ways. Ultimately, nanofibers may have the potential to precisely form whole organs for tissue engineering, regenerative medicine, and cellular agriculture, as well as to create in vitro microenvironments. In this review, the focus will be on the mechanical and physical characteristics such as porosity, fiber diameter, crystallinity, mechanical strength, alignment, and topography of the nanofiber scaffolds, and the impact on cell proliferation, migration, and differentiation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 11050039 2079-6439 |
| Relation: | https://www.mdpi.com/2079-6439/11/5/39; https://doaj.org/toc/2079-6439 |
| DOI: | 10.3390/fib11050039 |
| URL الوصول: | https://doaj.org/article/5c42153d52de4f239f8e0a59a108f01a |
| رقم الأكسشن: | edsdoj.5c42153d52de4f239f8e0a59a108f01a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11050039 20796439 |
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| DOI: | 10.3390/fib11050039 |