دورية أكاديمية
Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism
| العنوان: | Preliminary Studies on Biodegradable Zinc Oxide Nanoparticles Doped with Fe as a Potential Form of Iron Delivery to the Living Organism |
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| المؤلفون: | Paula Kielbik, Jarosław Kaszewski, Bartłomiej Dominiak, Magdalena Damentko, Izabela Serafińska, Julita Rosowska, Mikołaj A. Gralak, Marcin Krajewski, Bartłomiej S. Witkowski, Zdzislaw Gajewski, Marek Godlewski, Michal M. Godlewski |
| المصدر: | Nanoscale Research Letters, Vol 14, Iss 1, Pp 1-13 (2019) |
| بيانات النشر: | SpringerOpen, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials |
| مصطلحات موضوعية: | ZnO:Fe, Nanoparticles, Iron deficiency, Iron delivery, Iron doping, Materials of engineering and construction. Mechanics of materials, TA401-492 |
| الوصف: | Abstract Iron is the crucial element for living organisms and its deficiency is described as the most common nutritional disorder all over the world. Nowadays, more effective and safe iron supplementation strategies for both humans and animals become one of the most important challenges in the therapy of nutritional deficiencies. Our previous in vivo studies confirmed safety and biodegradability of in-house manufactured zinc oxide-based nanoparticles and their rapid distribution to majority of organs and tissues in the body. In vitro examinations performed on Caco-2 cell line, a model of epithelial cells of the gastrointestinal tract, revealed a low toxicity of studied nanomaterials. In the current study, we investigated biodegradable zinc oxide nanoparticles doped with Fe(III) as a perspective supplementation strategy for iron deficiency. Biodegradable ZnO:Fe nanoparticles were intra-gastrically administered to adult mice and following 24 h, animals were sacrificed with collection of internal organs for further analyses. The iron concentration measured with atomic absorption spectrometry and histological staining (Perl’s method) showed a rapid distribution of iron-doped nanoparticles to tissues specifically related with iron homeostasis. Accumulation of iron was also visible within hepatocytes and around blood vessels within the spleen, which might indicate the transfer of Fe-doped nanoparticles from the bloodstream into the tissue. Reassuming, preliminary results obtained in the current study suggest that biodegradable ZnO nanoparticles doped with Fe might be a good carriers of exogenous iron in the living body. Therefore, subsequent investigations focus on determination an exact mechanisms related with an iron deposition in the tissue and influence of nanoparticle carriers on iron metabolism are required. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1931-7573 1556-276X |
| Relation: | https://doaj.org/toc/1931-7573; https://doaj.org/toc/1556-276X |
| DOI: | 10.1186/s11671-019-3217-2 |
| URL الوصول: | https://doaj.org/article/a5c784d2c41a47039850a281bed3b957 |
| رقم الأكسشن: | edsdoj.5c784d2c41a47039850a281bed3b957 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 19317573 1556276X |
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| DOI: | 10.1186/s11671-019-3217-2 |