دورية أكاديمية
أعرض في EDS

FLT3‐ITD mutations in acute myeloid leukaemia – molecular characteristics, distribution and numerical variation

التفاصيل البيبلوغرافية
العنوان: FLT3‐ITD mutations in acute myeloid leukaemia – molecular characteristics, distribution and numerical variation
المؤلفون: Caroline Engen, Monica Hellesøy, Tim Grob, Adil Al Hinai, Atle Brendehaug, Line Wergeland, Siv Lise Bedringaas, Randi Hovland, Peter J. M. Valk, Bjørn T. Gjertsen
المصدر: Molecular Oncology, Vol 15, Iss 9, Pp 2300-2317 (2021)
بيانات النشر: Wiley, 2021.
سنة النشر: 2021
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: acute myeloid leukaemia, FLT3‐ITD, length mutation, outcome, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Recurrent somatic internal tandem duplications (ITD) in the FMS‐like tyrosine kinase 3 (FLT3) gene characterise approximately one third of patients with acute myeloid leukaemia (AML), and FLT3‐ITD mutation status guides risk‐adapted treatment strategies. The aim of this work was to characterise FLT3‐ITD variant distribution in relation to molecular and clinical features, and overall survival in adult AML patients. We performed two parallel retrospective cohort studies investigating FLT3‐ITD length and expression by cDNA fragment analysis, followed by Sanger sequencing in a subset of samples. In the two cohorts, a total of 139 and 172 mutant alleles were identified in 111 and 123 patients, respectively, with 22% and 28% of patients presenting with more than one mutated allele. Further, 15% and 32% of samples had a FLT3‐ITD total variant allele frequency (VAF)
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1878-0261
1574-7891
Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261
DOI: 10.1002/1878-0261.12961
URL الوصول: https://doaj.org/article/5c847808f7ca4069b952cc2692905f06
رقم الأكسشن: edsdoj.5c847808f7ca4069b952cc2692905f06
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:18780261
15747891
DOI:10.1002/1878-0261.12961