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Bovine Lactoferrin Inhibits Dengue Virus Infectivity by Interacting with Heparan Sulfate, Low-Density Lipoprotein Receptor, and DC-SIGN

التفاصيل البيبلوغرافية
العنوان: Bovine Lactoferrin Inhibits Dengue Virus Infectivity by Interacting with Heparan Sulfate, Low-Density Lipoprotein Receptor, and DC-SIGN
المؤلفون: Jo-Mei Chen, Yi-Chin Fan, Jen-Wei Lin, Yi-Ying Chen, Wei-Li Hsu, Shyan-Song Chiou
المصدر: International Journal of Molecular Sciences, Vol 18, Iss 9, p 1957 (2017)
بيانات النشر: MDPI AG, 2017.
سنة النشر: 2017
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: dengue virus, bovine lactoferrin, heparan sulfate, low-density lipoprotein receptor, DC-SIGN, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Bovine lactoferrin (bLF) presents in milk and has been shown to inhibit several viral infections. Effective drugs are unavailable for the treatment of dengue virus (DENV) infection. In this study, we evaluated the antiviral effect of bLF against DENV infection in vivo and in vitro. Bovine LF significantly inhibited the infection of the four serotypes of DENV in Vero cells. In the time-of-drug addition test, DENV-2 infection was remarkably inhibited when bLF was added during or prior to the occurrence of virus attachment. We also revealed that bovine LF blocks binding between DENV-2 and the cellular membrane by interacting with heparan sulfate (HS), dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN), and low-density lipoprotein receptors (LDLR). In addition, bLF inhibits DENV-2 infection and decreases morbidity in a suckling mouse challenge model. This study supports the finding that bLF may inhibit DENV infection by binding to the potential DENV receptors.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
Relation: https://www.mdpi.com/1422-0067/18/9/1957; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms18091957
URL الوصول: https://doaj.org/article/5ca1ce156ac840e1bb77c9232f2f7e82
رقم الأكسشن: edsdoj.5ca1ce156ac840e1bb77c9232f2f7e82
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms18091957