دورية أكاديمية
أعرض في EDS

Volumetric and structural connectivity abnormalities co-localise in TLE

التفاصيل البيبلوغرافية
العنوان: Volumetric and structural connectivity abnormalities co-localise in TLE
المؤلفون: Jonathan J. Horsley, Gabrielle M. Schroeder, Rhys H. Thomas, Jane de Tisi, Sjoerd B. Vos, Gavin P. Winston, John S. Duncan, Yujiang Wang, Peter N. Taylor
المصدر: NeuroImage: Clinical, Vol 35, Iss , Pp 103105- (2022)
بيانات النشر: Elsevier, 2022.
سنة النشر: 2022
المجموعة: LCC:Computer applications to medicine. Medical informatics
LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: Epilepsy, MRI, Volume, Connection, Network, Duration, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
الوصف: Patients with temporal lobe epilepsy (TLE) exhibit both volumetric and structural connectivity abnormalities relative to healthy controls. How these abnormalities inter-relate and their mechanisms are unclear. We computed grey matter volumetric changes and white matter structural connectivity abnormalities in 144 patients with unilateral TLE and 96 healthy controls. Regional volumes were calculated using T1-weighted MRI, while structural connectivity was derived using white matter fibre tractography from diffusion-weighted MRI. For each regional volume and each connection strength, we calculated the effect size between patient and control groups in a group-level analysis. We then applied hierarchical regression to investigate the relationship between volumetric and structural connectivity abnormalities in individuals. Additionally, we quantified whether abnormalities co-localised within individual patients by computing Dice similarity scores. In TLE, white matter connectivity abnormalities were greater when joining two grey matter regions with abnormal volumes. Similarly, grey matter volumetric abnormalities were greater when joined by abnormal white matter connections. The extent of volumetric and connectivity abnormalities related to epilepsy duration, but co-localisation did not. Co-localisation was primarily driven by neighbouring abnormalities in the ipsilateral hemisphere. Overall, volumetric and structural connectivity abnormalities were related in TLE. Our results suggest that shared mechanisms may underlie changes in both volume and connectivity alterations in patients with TLE.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2213-1582
Relation: http://www.sciencedirect.com/science/article/pii/S221315822200170X; https://doaj.org/toc/2213-1582
DOI: 10.1016/j.nicl.2022.103105
URL الوصول: https://doaj.org/article/5cd3303807584191be1d72dda4c4b17b
رقم الأكسشن: edsdoj.5cd3303807584191be1d72dda4c4b17b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22131582
DOI:10.1016/j.nicl.2022.103105