دورية أكاديمية

Protective effects of cupressuflavone against doxorubicin-induced hepatic damage in rats

التفاصيل البيبلوغرافية
العنوان: Protective effects of cupressuflavone against doxorubicin-induced hepatic damage in rats
المؤلفون: Muhammad Faisal Hayat, Moazama Batool, Hussain Ahmed, Rabia Azmat, Mukhtar Ahmed, Mian Nadeem Riaz
المصدر: Journal of King Saud University: Science, Vol 36, Iss 7, Pp 103240- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Science (General)
مصطلحات موضوعية: Cupressuflavone, Oxidative stress, Doxorubicin, Inflammation, Hepatoprotective, Apoptosis, Science (General), Q1-390
الوصف: Doxorubicin (DOX) is a potent chemotherapeutic agent that is used in various sorts of malignancies. However, its uses are restricted owing to its deleterious effects on different organs including the liver. Cupressuflavone (CUP) is a plant-based flavonoid which is well known for its biological as well pharmacological potential. Our investigation aimed to evaluate the ameliorative potential of CUP against DOX provoked liver toxicity in rats. Twenty-four albino rats (Rattus norvegicus) were distributed into four distinct groups such as control, DOX (3 mg/kg), co- administrated DOX (3 mg/kg) + CUP (40 mg/kg) and CUP (40 mg/kg) only. DOX exposure reduced catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), Glutathione reductase (GSR), glutathione-S-transferase (GST) activities and glutathione (GSH) content while escalating the levels of reactive oxygen species (ROS) and malondialdehyde (MDA). Besides, the levels of ALT, AST and ALP were increased in response to DOX exposure. Furthermore, administration of DOX upregulated the levels of Interleukin-6 (IL-6), Nuclear factor kappa-B (NF-κB), Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and the activity of cyclooxygenase-2 (COX-2). The treatment of DOX reduced the levels of Bcl-2 while escalating the levels of Caspase-3, Caspase-9 and Bax. Similarly, DOX intoxication instigated various histopathological disruptions in hepatic tissues of rats. However, supplementation of CUP notably (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1018-3647
Relation: http://www.sciencedirect.com/science/article/pii/S1018364724001526; https://doaj.org/toc/1018-3647
DOI: 10.1016/j.jksus.2024.103240
URL الوصول: https://doaj.org/article/5d017fc27f2c4e3984355c7ca9dfd80b
رقم الأكسشن: edsdoj.5d017fc27f2c4e3984355c7ca9dfd80b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:10183647
DOI:10.1016/j.jksus.2024.103240