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Comparative study on grey matter structure MRI between amyotrophic lateral sclerosis patients with limb-onset and bulbar-onset

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العنوان: Comparative study on grey matter structure MRI between amyotrophic lateral sclerosis patients with limb-onset and bulbar-onset
المؤلفون: SHEN Dong-chao, ZOU Peng, HOU Bo, YANG Xun-zhe, LIU Ming-sheng, CUI Li-ying
المصدر: Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 22, Iss 7, Pp 601-607 (2022)
بيانات النشر: Tianjin Huanhu Hospital, 2022.
سنة النشر: 2022
المجموعة: LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: amyotrophic lateral sclerosis, gray matter, magnetic resonance imaging, Neurology. Diseases of the nervous system, RC346-429
الوصف: Objective To compare the differences between the gray matter structures of amyotrophic lateral sclerosis (ALS) patients with limb-onset and bulbar-onset. Methods A total of 35 ALS patients with normal cognitive function were enrolled in Peking Union Medical College Hospital ALS Registry Platform from September 2013 to March 2018, and 20 healthy controls with matched age and education were included in the study. ALS patients were divided into limb-onset group (ALS-L group, n = 20) and bulbar-onset group (ALS-B group, n = 15) according to their clinical onset sites. Three-dimensional T1-fast spoiled gradient-recalled (3D-T1-FSPGR) of all subjects was collected. Gray matter volume of each group were compared using voxel-based morphometry (VBM). Within the compound region of interest (ROI) consisting of bilateral primary motor cortex, premotor cortex and supplementary motor area, the atrophy patterns of the motor cortex were compared between ALS-L group and ALS-B group. Results Compared with the control group, the ALS-L group had decreased gray matter volume in the left superior temporal gyrus-temporal pole (t = 3.932, uncorrected P < 0.001), left middle temporal gyrus (t = 3.836, uncorrected P < 0.001), right insula (t = 3.992, uncorrected P < 0.001). Compared with the ALS-B group, the ALS-L group had decreased gray matter volume in the right superior frontal gyrus (t = -3.158, uncorrected P < 0.001), left cingulate gyrus (t = -3.002, uncorrected P < 0.001). In the analysis of the motor cortex as ROI, the gray matter volume of the segments representing hand (t = 2.237, uncorrected P < 0.001) and lower limb (t = 2.728, uncorrected P < 0.001) of the left motor cortex in the ALS-L group was reduced significantly than that of ALS-B group. Conclusions ALS-L has more significant gray matter atrophy than ALS-B, and the local atrophy pattern of motor cortex in ALS patients corresponds to its functional disability.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
Chinese
تدمد: 1672-6731
Relation: http://www.cjcnn.org/index.php/cjcnn/article/view/2534; https://doaj.org/toc/1672-6731
DOI: 10.3969/j.issn.1672⁃6731.2022.07.009
URL الوصول: https://doaj.org/article/5d2d13654bf4441a8a4b57625b081d49
رقم الأكسشن: edsdoj.5d2d13654bf4441a8a4b57625b081d49
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16726731
DOI:10.3969/j.issn.1672⁃6731.2022.07.009