دورية أكاديمية
F-53B mediated ROS affects uterine development in rats during puberty by inducing apoptosis
| العنوان: | F-53B mediated ROS affects uterine development in rats during puberty by inducing apoptosis |
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| المؤلفون: | Penghui Nie, Yuzhi Lan, Tao You, Tiantian Jia, Hengyi Xu |
| المصدر: | Ecotoxicology and Environmental Safety, Vol 277, Iss , Pp 116399- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Environmental pollution LCC:Environmental sciences |
| مصطلحات موضوعية: | F-53B, Uterine development, Apoptosis, Reactive oxygen species, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| الوصف: | Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as pollutants, can cause palpable environmental and health impacts around the world, as endocrine disruptors, can disrupt endocrine homeostasis and increase the risk of diseases. Chlorinated polyfluoroalkyl ether sulfonate (F-53B), as a substitute for PFAS, was determined to have potential toxicity. Puberty is the stage when sexual organs develop and hormones change dramatically, and abnormal uterine development can increase the risk of uterine lesions and lead to infertility. This study was designed to explore the impact of F-53B on uterine development during puberty. Four-week-old female SD rats were exposed to 0.125 and 6.25 mg/L F-53B during puberty. The results showed that F-53B interfered with growth and sex hormone levels and bound to oestrogen-related receptors, which affected their function, contributed to the accumulation of reactive oxygen species, promoted cell apoptosis and inhibited cell proliferation, ultimately causing uterine dysplasia. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0147-6513 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0147651324004755; https://doaj.org/toc/0147-6513 |
| DOI: | 10.1016/j.ecoenv.2024.116399 |
| URL الوصول: | https://doaj.org/article/ee5d33bba26a49a4a08290064b6b9923 |
| رقم الأكسشن: | edsdoj.5d33bba26a49a4a08290064b6b9923 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 01476513 |
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| DOI: | 10.1016/j.ecoenv.2024.116399 |