دورية أكاديمية
A prospective comparative study from India between living genetically related and unrelated donor renal transplants
| العنوان: | A prospective comparative study from India between living genetically related and unrelated donor renal transplants |
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| المؤلفون: | Nitin Agarwal, Anil Kumar Singh Rana, Aakansh Jain |
| المصدر: | Indian Journal of Transplantation, Vol 16, Iss 2, Pp 211-215 (2022) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Surgery |
| مصطلحات موضوعية: | acute rejection, living related donors, renal transplant, unrelated spousal donors, Surgery, RD1-811 |
| الوصف: | Background: India has a significant backlog in terms of renal transplant waiting lists, and progress of deceased donor transplant is limited by social and cultural hurdles. Newer strategies in living donation are needed. Materials and Methods: A prospective comparative study was conducted at our tertiary hospital over 3 years, between living related donor (LRD) and living unrelated donor (LURD) renal transplant outcomes, chiefly acute rejection and graft dysfunction. Confounding variables and outcome parameters such as mortality, hospital stay >21 days, and complications were recorded for 6 months. Results: LRD (n = 78) and LURD (n = 42) groups differed significantly in median recipient age (25 [22–34] vs. 40 [33–50] years; P < 0.001) and human leukocyte antigen (HLA) mismatches >3 (3/78 [3.8%] vs. 32/78 [76.2%]; P < 0.001, respectively). Yet, there was no significant difference in donor age, gender, immunosuppression, preoperative hemodialysis, nephrectomy time, or warm ischemia time. No significant difference was noted between LRD and LURD in acute rejection rate, graft dysfunction at 1 week and 6 months, mortality, hospital stay >21 days, or complication rate. Among factors predictive for acute rejection, only anastomotic time had a significant association (β coefficient = 0.006 [0.001–0.010]; Pearson's coefficient “r” =0.208; P < 0.01), while for early graft dysfunction, it was only mean donor nephrectomy time in minutes (β coefficient=-0.002 [−0.004–0.000]; Pearson's coefficient “r” = −0.158; P = 0.042). Conclusion: Despite differences in HLA-mismatches and age, LRD and LURD had a similar short-term outcome with respect to acute rejection and graft dysfunction. This is linked to better and standardized immunosuppression available, making it possible to expand the scope of LURD beyond spousal, within the legal and ethical boundaries. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2212-0017 2212-0025 |
| Relation: | http://www.ijtonline.in/article.asp?issn=2212-0017;year=2022;volume=16;issue=2;spage=211;epage=215;aulast=Agarwal; https://doaj.org/toc/2212-0017; https://doaj.org/toc/2212-0025 |
| DOI: | 10.4103/ijot.ijot_51_21 |
| URL الوصول: | https://doaj.org/article/5d401c94757d4c399ecbd76c2bb5fb84 |
| رقم الأكسشن: | edsdoj.5d401c94757d4c399ecbd76c2bb5fb84 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22120017 22120025 |
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| DOI: | 10.4103/ijot.ijot_51_21 |