دورية أكاديمية
Targeting E3 ubiquitin ligases and their adaptors as a therapeutic strategy for metabolic diseases
| العنوان: | Targeting E3 ubiquitin ligases and their adaptors as a therapeutic strategy for metabolic diseases |
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| المؤلفون: | Yelin Jeong, Ah-Reum Oh, Young Hoon Jung, HyunJoon Gi, Young Un Kim, KyeongJin Kim |
| المصدر: | Experimental and Molecular Medicine, Vol 55, Iss 10, Pp 2097-2104 (2023) |
| بيانات النشر: | Nature Publishing Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Biochemistry |
| مصطلحات موضوعية: | Medicine, Biochemistry, QD415-436 |
| الوصف: | Abstract Posttranslational modification of proteins via ubiquitination determines their activation, translocation, dysregulation, or degradation. This process targets a large number of cellular proteins, affecting all biological pathways involved in the cell cycle, development, growth, and differentiation. Thus, aberrant regulation of ubiquitination is likely associated with several diseases, including various types of metabolic diseases. Among the ubiquitin enzymes, E3 ubiquitin ligases are regarded as the most influential ubiquitin enzymes due to their ability to selectively bind and recruit target substrates for ubiquitination. Continued research on the regulatory mechanisms of E3 ligases and their adaptors in metabolic diseases will further stimulate the discovery of new targets and accelerate the development of therapeutic options for metabolic diseases. In this review, based on recent discoveries, we summarize new insights into the roles of E3 ubiquitin ligases and their adaptors in the pathogenesis of metabolic diseases by highlighting recent evidence obtained in both human and animal model studies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2092-6413 |
| Relation: | https://doaj.org/toc/2092-6413 |
| DOI: | 10.1038/s12276-023-01087-w |
| URL الوصول: | https://doaj.org/article/5da84159ed644456ab106ecc04f8f4ff |
| رقم الأكسشن: | edsdoj.5da84159ed644456ab106ecc04f8f4ff |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20926413 |
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| DOI: | 10.1038/s12276-023-01087-w |