Abstract Background Chronic obstructive pulmonary disease (COPD) frequently coexists with other chronic diseases, namely comorbidities. They negatively impact prognosis, exacerbations and quality of life in COPD patients. However, no studies have been performed to explore the impact of these comorbidities on COPD clinical control criteria. Research question Determine the relationship between individualized comorbidities and COPD clinical control criteria. Study design and methods Observational, multicenter, cross-sectional study performed in Spain involving 4801 patients with severe COPD (
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