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Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review

التفاصيل البيبلوغرافية
العنوان: Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review
المؤلفون: Nurliana Abd Mutalib, Sharifah Aminah Syed Mohamad, Nor Atiqah Jusril, Nur Intan Hasbullah, Mohd Cairul Iqbal Mohd Amin, Nor Hadiani Ismail
المصدر: Pharmaceuticals, Vol 16, Iss 5, p 712 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Pharmacy and materia medica
مصطلحات موضوعية: lactic acid bacteria, LAB, probiotics, neuroprotection, neurodegenerative diseases, Alzheimer’s, Medicine, Pharmacy and materia medica, RS1-441
الوصف: Background: In recent years, the potential role of probiotics has become prominent in the discoveries of neurotherapy against neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. Lactic acid bacteria (LAB) exhibit neuroprotective properties and exert their effects via various mechanisms of actions. This review aimed to evaluate the effects of LAB on neuroprotection reported in the literature. Methods: A database search on Google Scholar, PubMed, and Science Direct revealed a total of 467 references, of which 25 were included in this review based on inclusion criteria which comprises 7 in vitro, 16 in vivo, and 2 clinical studies. Results: From the studies, LAB treatment alone or in probiotics formulations demonstrated significant neuroprotective activities. In animals and humans, LAB probiotics supplementation has improved memory and cognitive performance mainly via antioxidant and anti-inflammatory pathways. Conclusions: Despite promising findings, due to limited studies available in the literature, further studies still need to be explored regarding synergistic effects, efficacy, and optimum dosage of LAB oral bacteriotherapy as treatment or prevention against neurodegenerative diseases.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1424-8247
Relation: https://www.mdpi.com/1424-8247/16/5/712; https://doaj.org/toc/1424-8247
DOI: 10.3390/ph16050712
URL الوصول: https://doaj.org/article/e5dcfdba8a844e3f912d1df51e21a6ab
رقم الأكسشن: edsdoj.5dcfdba8a844e3f912d1df51e21a6ab
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14248247
DOI:10.3390/ph16050712