دورية أكاديمية
Applying a Radiation Therapy Volume Analysis Pipeline to Determine the Utility of Spectroscopic MRI-Guided Adaptive Radiation Therapy for Glioblastoma
| العنوان: | Applying a Radiation Therapy Volume Analysis Pipeline to Determine the Utility of Spectroscopic MRI-Guided Adaptive Radiation Therapy for Glioblastoma |
|---|---|
| المؤلفون: | Anuradha G. Trivedi, Su Hyun Kim, Karthik K. Ramesh, Alexander S. Giuffrida, Brent D. Weinberg, Eric A. Mellon, Lawrence R. Kleinberg, Peter B. Barker, Hui Han, Hui-Kuo G. Shu, Hyunsuk Shim, Eduard Schreibmann |
| المصدر: | Tomography, Vol 9, Iss 3, Pp 1052-1061 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Computer applications to medicine. Medical informatics |
| مصطلحات موضوعية: | spectroscopic MRI, survival biomarkers, glioblastoma, adaptive radiation therapy planning, Computer applications to medicine. Medical informatics, R858-859.7 |
| الوصف: | Accurate radiation therapy (RT) targeting is crucial for glioblastoma treatment but may be challenging using clinical imaging alone due to the infiltrative nature of glioblastomas. Precise targeting by whole-brain spectroscopic MRI, which maps tumor metabolites including choline (Cho) and N-acetylaspartate (NAA), can quantify early treatment-induced molecular changes that other traditional modalities cannot measure. We developed a pipeline to determine how spectroscopic MRI changes during early RT are associated with patient outcomes to provide insight into the utility of adaptive RT planning. Data were obtained from a study (NCT03137888) where glioblastoma patients received high-dose RT guided by the pre-RT Cho/NAA twice normal (Cho/NAA ≥ 2x) volume, and received spectroscopic MRI scans pre- and mid-RT. Overlap statistics between pre- and mid-RT scans were used to quantify metabolic activity changes after two weeks of RT. Log-rank tests were used to quantify the relationship between imaging metrics and patient overall and progression-free survival (OS/PFS). Patients with lower Jaccard/Dice coefficients had longer PFS (p = 0.045 for both), and patients with lower Jaccard/Dice coefficients had higher OS trending towards significance (p = 0.060 for both). Cho/NAA ≥ 2x volumes changed significantly during early RT, putting healthy tissue at risk of irradiation, and warranting further study into using adaptive RT planning. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2379-139X 2379-1381 |
| Relation: | https://www.mdpi.com/2379-139X/9/3/86; https://doaj.org/toc/2379-1381; https://doaj.org/toc/2379-139X |
| DOI: | 10.3390/tomography9030086 |
| URL الوصول: | https://doaj.org/article/5e485b96372241f582bdefa0ac6356d7 |
| رقم الأكسشن: | edsdoj.5e485b96372241f582bdefa0ac6356d7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2379139X 23791381 |
|---|---|
| DOI: | 10.3390/tomography9030086 |