دورية أكاديمية
Phi-based risk calculators performed better in the prediction of prostate cancer in the Chinese population
| العنوان: | Phi-based risk calculators performed better in the prediction of prostate cancer in the Chinese population |
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| المؤلفون: | Yi-Shuo Wu, Xiao-Jian Fu, Rong Na, Ding-Wei Ye, Jun Qi, Xiao-Ling Lin, Fang Liu, Jian Gong, Ning Zhang, Guang-Liang Jiang, Hao-Wen Jiang, Qiang Ding, Jianfeng Xu, Ying-Hao Sun |
| المصدر: | Asian Journal of Andrology, Vol 21, Iss 6, Pp 592-597 (2019) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | chinese, p2psa, prostate biopsy, prostate health index, risk calculator, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Risk prediction models including the Prostate Health Index (phi) for prostate cancer have been well established and evaluated in the Western population. The aim of this study is to build phi-based risk calculators in a prostate biopsy population and evaluate their performance in predicting prostate cancer (PCa) and high-grade PCa (Gleason score ≥7) in the Chinese population. We developed risk calculators based on 635 men who underwent initial prostate biopsy. Then, we validated the performance of prostate-specific antigen (PSA), phi, and the risk calculators in an additional observational cohort of 1045 men. We observed that the phi-based risk calculators (risk calculators 2 and 4) outperformed the PSA-based risk calculator for predicting PCa and high-grade PCa in the training cohort. In the validation study, the area under the receiver operating characteristic curve (AUC) for risk calculators 2 and 4 reached 0.91 and 0.92, respectively, for predicting PCa and high-grade PCa, respectively; the AUC values were better than those for risk calculator 1 (PSA-based model with an AUC of 0.81 and 0.82, respectively) (all P < 0.001). Such superiority was also observed in the stratified population with PSA ranging from 2.0 ng ml−1to 10.0 ng ml−1. Decision curves confirmed that a considerable proportion of unnecessary biopsies could be avoided while applying phi-based risk calculators. In this study, we showed that, compared to risk calculators without phi, phi-based risk calculators exhibited superior discrimination and calibration for PCa in the Chinese biopsy population. Applying these risk calculators also considerably reduced the number of unnecessary biopsies for PCa. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1008-682X 1745-7262 |
| Relation: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2019;volume=21;issue=6;spage=592;epage=597;aulast=Wu; https://doaj.org/toc/1008-682X; https://doaj.org/toc/1745-7262 |
| DOI: | 10.4103/aja.aja_125_18 |
| URL الوصول: | https://doaj.org/article/5e55c524a2a549c1ae257a7a6e226db1 |
| رقم الأكسشن: | edsdoj.5e55c524a2a549c1ae257a7a6e226db1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1008682X 17457262 |
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| DOI: | 10.4103/aja.aja_125_18 |