دورية أكاديمية
Isolation from cattle of a prion strain distinct from that causing bovine spongiform encephalopathy.
| العنوان: | Isolation from cattle of a prion strain distinct from that causing bovine spongiform encephalopathy. |
|---|---|
| المؤلفون: | Vincent Béringue, Anna Bencsik, Annick Le Dur, Fabienne Reine, Thanh Lan Laï, Nathalie Chenais, Gaëlle Tilly, Anne-Gaëlle Biacabé, Thierry Baron, Jean-Luc Vilotte, Hubert Laude |
| المصدر: | PLoS Pathogens, Vol 2, Iss 10, p e112 (2006) |
| بيانات النشر: | Public Library of Science (PLoS), 2006. |
| سنة النشر: | 2006 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Biology (General) |
| مصطلحات موضوعية: | Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5 |
| الوصف: | To date, bovine spongiform encephalopathy (BSE) and its human counterpart, variant Creutzfeldt-Jakob disease, have been associated with a single prion strain. This strain is characterised by a unique and remarkably stable biochemical profile of abnormal protease-resistant prion protein (PrP(res)) isolated from brains of affected animals or humans. However, alternate PrP(res) signatures in cattle have recently been discovered through large-scale screening. To test whether these also represent separate prion strains, we inoculated French cattle isolates characterised by a PrP(res) of higher apparent molecular mass--called H-type--into transgenic mice expressing bovine or ovine PrP. All mice developed neurological symptoms and succumbed to these isolates, showing that these represent a novel strain of infectious prions. Importantly, this agent exhibited strain-specific features clearly distinct from that of BSE agent inoculated to the same mice, which were retained on further passage. Moreover, it also differed from all sheep scrapie isolates passaged so far in ovine PrP-expressing mice. Our findings therefore raise the possibility that either various prion strains may exist in cattle, or that the BSE agent has undergone divergent evolution in some animals. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1553-7366 1553-7374 |
| Relation: | https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374 |
| DOI: | 10.1371/journal.ppat.0020112 |
| URL الوصول: | https://doaj.org/article/5eb332d89e1a4a798284ef530a20c8ff |
| رقم الأكسشن: | edsdoj.5eb332d89e1a4a798284ef530a20c8ff |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15537366 15537374 |
|---|---|
| DOI: | 10.1371/journal.ppat.0020112 |