دورية أكاديمية
أعرض في EDS

Annexin A5 reduces early plaque formation in ApoE -/- mice.

التفاصيل البيبلوغرافية
العنوان: Annexin A5 reduces early plaque formation in ApoE -/- mice.
المؤلفون: Robert Stöhr, Leon Schurgers, Rick van Gorp, Armand Jaminon, Nikolaus Marx, Chris Reutelingsperger
المصدر: PLoS ONE, Vol 12, Iss 12, p e0190229 (2017)
بيانات النشر: Public Library of Science (PLoS), 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Annexin A5 (AnxA5) exerts anti-inflammatory, anticoagulant and anti-apoptotic effects through its binding to cell surface expressed phosphatidylserine. We previously showed that AnxA5 can stabilize advanced atherosclerotic plaques by reducing macrophage infiltration. We now investigated the effects of AnxA5 administration on the onset of atherosclerosis development. Eight-week-old ApoE-/-mice were fed a western diet while being administered AnxA5 or control (M1234) for a total of 6 weeks. AnxA5 administration reduced plaque size in the aortic root as well as the aortic arch by 36% and 55% respectively. As determined by immunohistochemistry, administration of AnxA5 further stabilized plaque by reducing macrophage content and increasing smooth muscle cell content. Furthermore, the pre-treatment of HUVEC's with AnxA5 reduced monocyte adhesion under flow-conditions. Finally, AnxA5 administration results in a trend to reduced cell death more pronounced in the aortic arch than the aortic root. In conclusion, treatment with AnxA5 before the onset of atherosclerosis reduces plaque formation in a murine model of atherosclerosis in part by reducing apoptotic rates further to its beneficial effect on macrophage infiltration and activation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC5739472?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0190229
URL الوصول: https://doaj.org/article/5ed58f08ef8a4f9c983e9e7a39512c6a
رقم الأكسشن: edsdoj.5ed58f08ef8a4f9c983e9e7a39512c6a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0190229