دورية أكاديمية
Rescue Endovascular Treatment of Patients With Emergent Large Vessel Occlusion Attributed to Intracranial Atherosclerosis: A Systematic Review and Meta‐Analysis
| العنوان: | Rescue Endovascular Treatment of Patients With Emergent Large Vessel Occlusion Attributed to Intracranial Atherosclerosis: A Systematic Review and Meta‐Analysis |
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| المؤلفون: | Eyad Almallouhi, Mohammad Hassan Murad, Reda Chalhoub, Kimberly P. Kicielinski, Jonathan Lena, Emily A. Brennan, Osama Zaidat, Adam de Havenon, Alejandro M. Spiotta, Sami Al Kasab |
| المصدر: | Stroke: Vascular and Interventional Neurology, Vol 3, Iss 1 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | angioplasty, ICAD, intracranial atheroscelrosis, mechanical thrombectomy, rescue therapy, stenting, Neurology. Diseases of the nervous system, RC346-429, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background Patients with acute stroke presenting with large vessel occlusion secondary to intracranial atherosclerosis (ICAS‐LVO) may require rescue therapy (RT) in addition to mechanical thrombectomy to achieve and maintain successful recanalization. We performed a systematic review and meta‐analysis of comparative studies that reported outcomes of RT in patients with ICAS‐LVO to evaluate its safety and efficacy. Methods Databases searched include PubMed, CINAHL Complete, and Scopus from database date of inception through August 17, 2021. We included comparative studies that reported the outcomes of ICAS‐LVO RT compared with outcomes of patients with ICAS‐LVO who did not undergo RT or to those patients presenting with embolic large vessel occlusion (non–ICAS‐LVO). Meta‐analysis using the random‐effects model was used to combine estimates reporting odds ratios (ORs) and 95% CIs. Results A total of 9 nonrandomized studies were included: 5 studies in ICAS‐LVO RT versus ICAS‐LVO non‐RT analysis and 5 in ICAS‐LVO RT versus non‐ICAS LVO analysis. Rescue treatments included intra‐arterial antiplatelets, angioplasty, stenting, or a combination of treatments. Compared with non‐RT ICAS‐LVO, RT was associated with an increased favorable 90‐day outcome (OR, 3.19 [95% CI, 1.91–5.32]; I2 = 14%) and decreased 90‐day mortality (OR, 0.35 [95% CI, 0.16–0.76]; I2 = 21%). In the analysis of ICAS‐LVO RT versus embolic LV, the incidence of favorable 90‐day outcome and 90‐day mortality did not differ between ICAS‐LVO RT and non–ICAS‐LVO (OR, 0.97 [95% CI, 0.58–1.64; I2 = 50%]; and OR, 1.22 [95% CI, 0.90–1.66; I2 = 0%], respectively). Conclusions Rescue treatment is likely associated with better outcomes in patients with ICAS‐LVO. The outcomes of patients with ICAS‐LVO who receive RT may be comparable with patients with embolic large vessel occlusion (non–ICAS‐LVO). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2694-5746 |
| Relation: | https://doaj.org/toc/2694-5746 |
| DOI: | 10.1161/SVIN.122.000510 |
| URL الوصول: | https://doaj.org/article/5ef194185959499eadeee4c1908c7c9a |
| رقم الأكسشن: | edsdoj.5ef194185959499eadeee4c1908c7c9a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26945746 |
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| DOI: | 10.1161/SVIN.122.000510 |