دورية أكاديمية
Use of Multifactorial Treatments to Address the Challenge of Translating Experimental Myocardial Infarct Reduction Strategies
| العنوان: | Use of Multifactorial Treatments to Address the Challenge of Translating Experimental Myocardial Infarct Reduction Strategies |
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| المؤلفون: | Julie L. Horton, Jitka Virag |
| المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 6, p 1449 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | myocardial infarction, cardioprotection, therapeutic strategies, ephrinA1, ischemia, reperfusion, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Myocardial tissue damage that occurs during an ischemic event leads to a spiraling deterioration of cardiac muscle structural and functional integrity. Reperfusion is the only known efficacious strategy and is the most commonly used treatment to reduce injury and prevent remodeling. However, timing is critical, and the procedure is not always feasible for a variety of reasons. The complex molecular basis for cardioprotection has been studied for decades but formulation of a viable therapeutic that can significantly attenuate myocardial injury remains elusive. In this review, we address barriers to the development of a fruitful approach that will substantially improve the prognosis of those suffering from this widespread and largely unmitigated disease. Furthermore, we proffer that ephrinA1, a candidate molecule that satisfies many of the important criteria discussed, possesses robust potential to overcome these hurdles and thus offers protection that surpasses the limitations currently observed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| Relation: | https://www.mdpi.com/1422-0067/20/6/1449; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms20061449 |
| URL الوصول: | https://doaj.org/article/5ef43e8150a0437abf7123a36513f94b |
| رقم الأكسشن: | edsdoj.5ef43e8150a0437abf7123a36513f94b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms20061449 |