دورية أكاديمية
أعرض في EDS

Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype.

التفاصيل البيبلوغرافية
العنوان: Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype.
المؤلفون: Yeon-Jung Kim, Heun-Sik Lee, Yun Kyoung Kim, Suyeon Park, Jeong-Min Kim, Jun Ho Yun, Ho-Yeong Yu, Bong-Jo Kim
المصدر: PLoS ONE, Vol 11, Iss 6, p e0156612 (2016)
بيانات النشر: Public Library of Science (PLoS), 2016.
سنة النشر: 2016
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: The single nucleotide polymorphism rs9939609 of the gene FTO, which encodes fat mass and obesity-associated protein, is strongly associated with obesity and type 2 diabetes (T2D) in multiple populations; however, the underlying mechanism of this association is unclear. The present study aimed to investigate FTO genotype-dependent metabolic changes in obesity and T2D. To elucidate metabolic dysregulation associated with disease risk genotype, genomic and metabolomic datasets were recruited from 2,577 participants of the Korean Association REsource (KARE) cohort, including 40 homozygous carriers of the FTO risk allele (AA), 570 heterozygous carriers (AT), and 1,967 participants carrying no risk allele (TT). A total of 134 serum metabolites were quantified using a targeted metabolomics approach. Through comparison of various statistical methods, seven metabolites were identified that are significantly altered in obesity and T2D based on the FTO risk allele (adjusted p < 0.05). These identified metabolites are relevant to phosphatidylcholine metabolic pathway, and previously reported to be metabolic markers of obesity and T2D. In conclusion, using metabolomics with the information from genome-wide association studies revealed significantly altered metabolites depending on the FTO genotype in complex disorders. This study may contribute to a better understanding of the biological mechanisms linking obesity and T2D.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4889059?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0156612
URL الوصول: https://doaj.org/article/e5f422b10284469eb20e59547237623e
رقم الأكسشن: edsdoj.5f422b10284469eb20e59547237623e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0156612