دورية أكاديمية
Effects of Electronic Cigarette Exposure on Myocardial Infarction and No-Reflow, and Cardiac Function in a Rat Model
| العنوان: | Effects of Electronic Cigarette Exposure on Myocardial Infarction and No-Reflow, and Cardiac Function in a Rat Model |
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| المؤلفون: | Wangde Dai MD, Jianru Shi PhD, Prabha Siddarth PhD, Lifu Zhao MD, Juan Carreno DVM, Michael T. Kleinman PhD, David A. Herman PhD, Rebecca J. Arechavala PhD, Samantha Renusch BS, Irene Hasen BS, Amanda Ting BS, Robert A. Kloner MD, PhD |
| المصدر: | Journal of Cardiovascular Pharmacology and Therapeutics, Vol 28 (2023) |
| بيانات النشر: | SAGE Publishing, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Diseases of the circulatory (Cardiovascular) system, RC666-701, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Purpose: We investigated the effects of exposure to electronic cigarettes (E-cig) vapor on the sizes of the no-reflow and myocardial infarction regions, and cardiovascular function compared to exposure to purified air and standard cigarette smoke. Methods and Results: Sprague Dawley rats (both male and female, 6 weeks old) were successfully exposed to filtered air (n = 32), E-cig with nicotine (E-cig Nic + , n = 26), E-cig without nicotine (E-cig Nic − , n = 26), or standard cigarette smoke (1R6F reference, n = 31). All rats were exposed to inhalation exposure for 8 weeks, prior to being subjected to 30 minutes of left coronary artery occlusion followed by 3 hours of reperfusion. Exposure to E-cig vapor with or without nicotine or exposure to standard cigarettes did not increase myocardial infarct size or worsen the no-reflow phenomenon. Exposure to E-cig Nic + reduced the body weight gain, and increased the LV weight normalized to body weight and LV wall thickness and enhanced the collagen deposition within the LV wall. E-cig exposure led to cardiovascular dysfunction, such as reductions in cardiac output, LV positive and negative dp/dt, suggesting a reduction in contractility and relaxation, and increased systemic arterial resistance after coronary artery occlusion and reperfusion in rats compared to air or cigarette exposure. Conclusions: E-cig exposure did not increase myocardial infarct size or worsen the no-reflow phenomenon, but induced deleterious changes in LV structure leading to cardiovascular dysfunction and increased systemic arterial resistance after coronary artery occlusion followed by reperfusion. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1940-4034 10742484 96340886 |
| Relation: | https://doaj.org/toc/1940-4034 |
| DOI: | 10.1177/10742484231155992 |
| URL الوصول: | https://doaj.org/article/5f64c5814daf42bb8a9634088605c179 |
| رقم الأكسشن: | edsdoj.5f64c5814daf42bb8a9634088605c179 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19404034 10742484 96340886 |
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| DOI: | 10.1177/10742484231155992 |