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Apoptotic efficiency of aqueous extracts of turmeric, garlic and their active compounds in combination with Tamoxifen in lung and oral cancers: A comparative study

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العنوان: Apoptotic efficiency of aqueous extracts of turmeric, garlic and their active compounds in combination with Tamoxifen in lung and oral cancers: A comparative study
المؤلفون: Satish Kumar Vemuri, Rajkiran Reddy Banala, Subbaiah GPV, Gurva Reddy AV, Malarvili Thekkumalai
المصدر: Beni-Suef University Journal of Basic and Applied Sciences, Vol 7, Iss 2, Pp 184-197 (2018)
بيانات النشر: SpringerOpen, 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine (General)
LCC:Science
مصطلحات موضوعية: Medicine (General), R5-920, Science
الوصف: Anticancer treatment against oral and lung cancers has caught the eye of oncologist and researchers worldwide as most common cause deaths in India and worldwide is due to these cancers and most of the treatment strategies employed are not showing any effectiveness against neoplastic ability of the cancers. One of the reasons for cancer deaths could be because of poor prognosis and associated therapies. The existing cancer agents are being re-evaluated and development of new mechanisms of treatment being explored continuously, but it’s inadequate in offering treatment. Therefore, endeavors for new anticancer agents with high efficacy and considerable side effects still going on. The literature reviews shows numerous medicinal plants exhibiting anti-proliferative, pro-apoptotic, anti-metastatic and anti-angiogenic properties and these effects were reported by conducting both in vitro experiments and animal studies. Use of natural phytochemical compounds in cancer chemoprevention is an emerging strategy to forestall the cancer progression or cure cancer.In the present study we have attempted to evaluate the efficacy of Curcumin longa and Allium sativum aqueous extracts individually and in combination with its active compounds (Curcumin and Quercetin) and also with Tamoxifen hydrochloride. Our results suggest that aqueous extracts of Curcumin longa and Allium sativum were effective in inducing apoptosis and cell death in two immortal cell lines i.e. A549 and SCC-9 (Adeno carcinoma of lung, squamous cell carcinoma of tongue), but there was no apoptosis or cell senescence in normal cell line (HEK 293). There was significant increase in apoptosis and cell senescence in combination therapy. Hence a combination of natural extracts along with Tamoxifen can be considered an alternate in cancer treatments but this requires more research. Keywords: Curcumin longa, Allium sativum, Tamoxifen hydrochloride, A549, SCC-9, HEK 293 cell lines
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2314-8535
Relation: http://www.sciencedirect.com/science/article/pii/S2314853517303001; https://doaj.org/toc/2314-8535
DOI: 10.1016/j.bjbas.2017.10.006
URL الوصول: https://doaj.org/article/5f8fed0b4fef478da8e325dbabcbc1ab
رقم الأكسشن: edsdoj.5f8fed0b4fef478da8e325dbabcbc1ab
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23148535
DOI:10.1016/j.bjbas.2017.10.006