دورية أكاديمية
Metabolomic profiling to identify effects of dietary calcium reveal the influence of the individual and postprandial dynamics on the canine plasma metabolome
| العنوان: | Metabolomic profiling to identify effects of dietary calcium reveal the influence of the individual and postprandial dynamics on the canine plasma metabolome |
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| المؤلفون: | David Allaway, Matt Gilham, Antje Wagner-Golbs, Sandra González Maldonado, Richard Haydock, Alison Colyer, Jonathan Stockman, Phillip Watson |
| المصدر: | Journal of Nutritional Science, Vol 8 (2019) |
| بيانات النشر: | Cambridge University Press, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Medicine |
| مصطلحات موضوعية: | Canine nutrition, Nutritional metabolomics, Individual metabolomes, Postprandial metabolomes, Nutrition. Foods and food supply, TX341-641, Medicine |
| الوصف: | Short-term feeding studies have highlighted a phenomenon in Ca regulation that raises concerns around Ca absorption in dogs that may make an impact on commercial diets near to the maximum recommended level. A recent study to determine responses in dogs fed one of two diets differing in dietary Ca over 40 weeks found no evidence to suggest a concern across a range of biological parameters hypothesised to be affected by Ca. Unforeseen consequences of dietary Ca could have occurred and metabolic profiling was deemed a suitable data-driven approach to identify effects of dietary Ca. The objectives were to compare the fasted plasma metabolome (sampled at 8-week intervals over 40 weeks) of dogs fed one of two diets, near to the minimum and maximum recommended levels of dietary Ca. Comparisons with the control diet were also investigated across the postprandial time course (1–4 h) following acute (1 d) and long-term (24 weeks) feeding of the test diet. Comparing fasted plasma samples at each time point, no significant effect (adjusted P < 0·05) of diet on metabolites was observed. In the postprandial state, only phosphate was consistently different between diets and was explained by additional dietary P to maintain Ca:P. Metabolic profiling analysis supports the view that the dietary Ca upper limit is safe. Additionally, the canine plasma metabolome was characterised, providing insights into the stability of individual profiles across 40 weeks, the response to consumption of a nutritionally complete meal over a 4 h postprandial time course and different kinetic categories of postprandial absorption. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2048-6790 |
| Relation: | https://www.cambridge.org/core/product/identifier/S2048679019000120/type/journal_article; https://doaj.org/toc/2048-6790 |
| DOI: | 10.1017/jns.2019.12 |
| URL الوصول: | https://doaj.org/article/ddd5f9a9ed324aff8fb8413f2a7731be |
| رقم الأكسشن: | edsdoj.5f9a9ed324aff8fb8413f2a7731be |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20486790 |
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| DOI: | 10.1017/jns.2019.12 |