دورية أكاديمية
The Role of Angiotensin-Converting Enzyme (ACE) Polymorphisms in the Risk of Development and Treatment of Diabetic Nephropathy
| العنوان: | The Role of Angiotensin-Converting Enzyme (ACE) Polymorphisms in the Risk of Development and Treatment of Diabetic Nephropathy |
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| المؤلفون: | Magdalena Król-Kulikowska, Nikita Abramenko, Milan Jakubek, Mirosław Banasik, Marta Kepinska |
| المصدر: | Journal of Clinical Medicine, Vol 13, Iss 4, p 995 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | diabetes nephropathy, kidney transplant, single nucleotide polymorphisms, ACE inhibitors, molecular docking, Medicine |
| الوصف: | Background: Angiotensin-converting enzyme (ACE) is responsible for the production of angiotensin II, and increased production of angiotensin II is observed in diabetes. What is more, ACE polymorphisms may play a role in the development of diabetic nephropathy. The aim of this study was to assess the role of selected ACE polymorphisms (rs4343 and rs4646994) in the risk of development of diabetic nephropathy and in the likelihood of renal replacement therapy. Methods: ACE polymorphisms were analyzed in a group of 225 patients who were divided into three subgroups. The rs4343 polymorphism was determined using the PCR-RFLP, and the rs4646994 polymorphism was determined using the PCR. Molecular docking between domains of ACE and its ligands was performed by using AutoDock Vina. Results: The G/G genotype of rs4343 polymorphism is associated with increased odds of developing diabetic nephropathy. The G allele is also associated with a higher risk of this disease. Similar results were obtained in patients who had already had a kidney transplant as a result of diabetic nephropathy. Conclusions: The presence of G/G and G/A genotypes, and the G allele increases the likelihood of developing diabetic nephropathy. This may also be a risk factor for renal replacement therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13040995 2077-0383 |
| Relation: | https://www.mdpi.com/2077-0383/13/4/995; https://doaj.org/toc/2077-0383 |
| DOI: | 10.3390/jcm13040995 |
| URL الوصول: | https://doaj.org/article/d5f9b317ce3a4615ac902946d5001d9f |
| رقم الأكسشن: | edsdoj.5f9b317ce3a4615ac902946d5001d9f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13040995 20770383 |
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| DOI: | 10.3390/jcm13040995 |