دورية أكاديمية
Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography
| العنوان: | Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography |
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| المؤلفون: | Guo-Peng Yu, Rong Na, Ding-Wei Ye, Jun Qi, Fang Liu, Hai-Tao Chen, Yi-Shuo Wu, Gui-Ming Zhang, Jie-Lin Sun, Yao Zhu, Li-Qun Huang, Shan-Cheng Ren, De-Ke Jiang, S Lilly Zheng, Hao-Wen Jiang, Ying-Hao Sun, Qiang Ding, Jianfeng Xu |
| المصدر: | Asian Journal of Andrology, Vol 18, Iss 4, Pp 633-638 (2016) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | [-2]proPSA, prostate cancer, Prostate Health Index, prostate-specific antigen, receiver operating curve, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | The [-2]proPSA (p2PSA) and its derivatives, the p2PSA-to-free PSA ratio (%p2PSA), and the Prostate Health Index (PHI) have greatly improved discrimination between men with and without prostate cancer (PCa) in prostate biopsies. However, little is known about their performance in cases where a digital rectal examination (DRE) and transrectal ultrasonography (TRUS) are negative. A prospective cohort of 261 consecutive patients in China with negative DRE and TRUS were recruited and underwent prostate biopsies. A serum sample had collected before the biopsy was used to measure various PSA derivatives, including total prostate-specific antigen (tPSA), free PSA, and p2PSA. For each patient, the free-to-total PSA ratio (%fPSA), PSA density (PSAD), p2PSA-to-free PSA ratio (%p2PSA), and PHI were calculated. Discriminative performance was assessed using the area under the receiver operating characteristic curve (AUC) and the biopsy rate at 91% sensitivity. The AUC scores within the entire cohort with respect to age, tPSA, %fPSA, PSAD, p2PSA, %p2PSA, and PHI were 0.598, 0.751, 0.646, 0.789, 0.814, 0.808, and 0.853, respectively. PHI was the best predictor of prostate biopsy results, especially in patients with a tPSA of 10.1-20 ng ml−1 . Compared with other markers, at a sensitivity of 91%, PHI was the most useful for determining which men did not need to undergo biopsy, thereby avoiding unnecessary procedures. The use of PHI could improve the accuracy of PCa detection by predicting prostate biopsy outcomes among men with a negative DRE and TRUS in China. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1008-682X 1745-7262 |
| Relation: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=4;spage=633;epage=638;aulast=Yu; https://doaj.org/toc/1008-682X; https://doaj.org/toc/1745-7262 |
| DOI: | 10.4103/1008-682X.172823 |
| URL الوصول: | https://doaj.org/article/5fb59ef9a8f8474a82d7eabd9d483ea0 |
| رقم الأكسشن: | edsdoj.5fb59ef9a8f8474a82d7eabd9d483ea0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1008682X 17457262 |
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| DOI: | 10.4103/1008-682X.172823 |