دورية أكاديمية
Calcium dependence of neurotransmitter release at a high fidelity synapse
| العنوان: | Calcium dependence of neurotransmitter release at a high fidelity synapse |
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| المؤلفون: | Abdelmoneim Eshra, Hartmut Schmidt, Jens Eilers, Stefan Hallermann |
| المصدر: | eLife, Vol 10 (2021) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | synapse, release, calcium, vesicle fusion, vesicle priming, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | The Ca2+-dependence of the priming, fusion, and replenishment of synaptic vesicles are fundamental parameters controlling neurotransmitter release and synaptic plasticity. Despite intense efforts, these important steps in the synaptic vesicles’ cycle remain poorly understood due to the technical challenge in disentangling vesicle priming, fusion, and replenishment. Here, we investigated the Ca2+-sensitivity of these steps at mossy fiber synapses in the rodent cerebellum, which are characterized by fast vesicle replenishment mediating high-frequency signaling. We found that the basal free Ca2+ concentration ( |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/70408; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.70408 |
| URL الوصول: | https://doaj.org/article/5feb4b556d074411b3872d170f03cf59 |
| رقم الأكسشن: | edsdoj.5feb4b556d074411b3872d170f03cf59 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.70408 |