دورية أكاديمية
Metformin Is Associated with the Inhibition of Renal Artery AT1R/ET-1/iNOS Axis in a Rat Model of Diabetic Nephropathy with Suppression of Inflammation and Oxidative Stress and Kidney Injury
| العنوان: | Metformin Is Associated with the Inhibition of Renal Artery AT1R/ET-1/iNOS Axis in a Rat Model of Diabetic Nephropathy with Suppression of Inflammation and Oxidative Stress and Kidney Injury |
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| المؤلفون: | Amal F. Dawood, Amro Maarouf, Norah M. Alzamil, Maha A. Momenah, Ayed A. Shati, Nervana M. Bayoumy, Samaa S. Kamar, Mohamed A. Haidara, Asmaa M. ShamsEldeen, Hanaa Z. Yassin, Peter W. Hewett, Bahjat Al-Ani |
| المصدر: | Biomedicines, Vol 10, Iss 7, p 1644 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | diabetic nephropathy, AT1R/ET-1/iNOS axis, renal artery, mesangial expansion, kidney fibrosis, metformin, Biology (General), QH301-705.5 |
| الوصف: | Diabetes is the most common cause of end-stage renal disease, also called kidney failure. The link between the renal artery receptor angiotensin II type I (AT1R) and endothelin-1 (ET-1), involved in vasoconstriction, oxidative stress, inflammation and kidney fibrosis (collagen) in diabetes-induced nephropathy with and without metformin incorporation has not been previously studied. Diabetes (type 2) was induced in rats and another group started metformin (200 mg/kg) treatment 2 weeks prior to the induction of diabetes and continued on metformin until being culled at week 12. Diabetes significantly (p < 0.0001) modulated renal artery tissue levels of AT1R, ET-1, inducible nitric oxide synthase (iNOS), endothelial NOS (eNOS), and the advanced glycation end products that were protected by metformin. In addition, diabetes-induced inflammation, oxidative stress, hypertension, ketonuria, mesangial matrix expansion, and kidney collagen were significantly reduced by metformin. A significant correlation between the AT1R/ET-1/iNOS axis, inflammation, fibrosis and glycemia was observed. Thus, diabetes is associated with the augmentation of the renal artery AT1R/ET-1/iNOS axis as well as renal injury and hypertension while being protected by metformin. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 10071644 2227-9059 |
| Relation: | https://www.mdpi.com/2227-9059/10/7/1644; https://doaj.org/toc/2227-9059 |
| DOI: | 10.3390/biomedicines10071644 |
| URL الوصول: | https://doaj.org/article/600eb28520a941abbebb24d26f02891a |
| رقم الأكسشن: | edsdoj.600eb28520a941abbebb24d26f02891a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10071644 22279059 |
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| DOI: | 10.3390/biomedicines10071644 |