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Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions

التفاصيل البيبلوغرافية
العنوان: Treatment-resistant Lennox-Gastaut syndrome: therapeutic trends, challenges and future directions
المؤلفون: Ostendorf AP, Ng YT
المصدر: Neuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1131-1140 (2017)
بيانات النشر: Dove Medical Press, 2017.
سنة النشر: 2017
المجموعة: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: Lennox-Gastaut syndrome, epilepsy, epilepsy surgery, cannabidiol, epileptic encephalopathy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
الوصف: Adam P Ostendorf,1 Yu-Tze Ng2 1Department of Pediatrics, Neurology Section, Nationwide Children’s Hospital, The Ohio State University, Columbus, OH, 2Department of Pediatrics, Baylor College of Medicine, The Children’s Hospital of San Antonio, San Antonio, TX, USA Abstract: Lennox-Gastaut syndrome is a severe, childhood-onset electroclinical syndrome comprised of multiple seizure types, intellectual and behavioral disturbances and characteristic findings on electroencephalogram of slow spike and wave complexes and paroxysmal fast frequency activity. Profound morbidity often accompanies a common and severe seizure type, the drop attack. Seizures often remain refractory, or initial treatment efficacy fades. Few individuals are seizure free despite the development of multiple generations of antiseizure medications over decades and high-level evidence on several choices. Approved medications such as lamotrigine, topiramate, rufinamide, felbamate and clobazam have demonstrated efficacy in reducing seizure burden. Cannabidiol has emerged as a promising investigational therapy with vast social interest yet lacks a standard, approved formulation. Palliative surgical procedures, such as vagal nerve stimulation and corpus callosotomy may provide reduction in total seizures and drop attacks. Emerging evidence suggests that complete callosotomy provides greater improvement in seizures without additional side effects. Etiologies such as dysplasia or hypothalamic hamartoma may be amenable for focal resection and thus offer potential to reverse this devastating epileptic encephalopathy. Keywords: Lennox-Gastaut syndrome, epilepsy, epilepsy surgery, cannabidiol, epileptic encephalopathy
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1178-2021
Relation: https://www.dovepress.com/treatment-resistant-lennox-gastaut-syndrome-therapeutic-trends-challen-peer-reviewed-article-NDT; https://doaj.org/toc/1178-2021
URL الوصول: https://doaj.org/article/602d57df195d46dc9b7dc3c75d0b12ec
رقم الأكسشن: edsdoj.602d57df195d46dc9b7dc3c75d0b12ec
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:11782021