دورية أكاديمية
Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy
| العنوان: | Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy |
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| المؤلفون: | Yanhui Deng, Lifeng Qiao, Mingyan Du, Chao Qu, Ling Wan, Jie Li, Lulin Huang |
| المصدر: | Genes and Diseases, Vol 9, Iss 1, Pp 62-79 (2022) |
| بيانات النشر: | KeAi Communications Co., Ltd., 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Genetics |
| مصطلحات موضوعية: | Age-related macular degeneration, Diagnosis, Genetics, Mechanism, Target treatment, Medicine (General), R5-920, QH426-470 |
| الوصف: | Age-related macular degeneration (AMD) is a complex eye disorder and is the leading cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the central area of retina known as the macula and it is classified as early stage to late stage (advanced AMD). The advanced AMD is classified into the nonexudative or atrophic form (dry AMD) and the exudative or neovascular form (wet AMD). More severe vision loss is typically associated with the wet form. Multiple genetic factors, lipid metabolism, oxidative stress and aging, play a role in the etiology of AMD. Dysregulation in genetic to AMD is established to 46%–71% of disease contribution, with CFH and ARMS2/HTRA1 to be the two most notable risk loci among the 103 identified AMD associated loci so far. Chronic cigarette smoking is the most proven consistently risk living habits for AMD. Deep learning algorithm has been developed based on image recognition to distinguish wet AMD and normal macula with high accuracy. Currently, anti-vascular endothelial growth factor (VEGF) therapy is highly effective at treating wet AMD. Several new generation AMD drugs and iPSC-derived RPE cell therapy are in the clinical trial stage and are promising to improve AMD treatment in the near future. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-3042 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352304221000295; https://doaj.org/toc/2352-3042 |
| DOI: | 10.1016/j.gendis.2021.02.009 |
| URL الوصول: | https://doaj.org/article/60539f0a425a413baf7617915af588ac |
| رقم الأكسشن: | edsdoj.60539f0a425a413baf7617915af588ac |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23523042 |
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| DOI: | 10.1016/j.gendis.2021.02.009 |