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Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine.

التفاصيل البيبلوغرافية
العنوان: Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine.
المؤلفون: Nienke S van Ditzhuijzen, Mie Kurata, Mieke van den Heuvel, Oana Sorop, Richard W B van Duin, Ilona Krabbendam-Peters, Jurgen Ligthart, Karen Witberg, Magdalena Murawska, Brett Bouma, Martin Villiger, Hector M Garcia-Garcia, Patrick W Serruys, Felix Zijlstra, Gijs van Soest, Dirk-Jan Duncker, Evelyn Regar, Heleen M M van Beusekom
المصدر: PLoS ONE, Vol 12, Iss 9, p e0183419 (2017)
بيانات النشر: Public Library of Science (PLoS), 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: DM remains a risk factor for poor outcome after stent-implantation, but little is known if and how DM affects the vascular response to BVS.The aim of our study was to examine coronary responses to bioresorbable vascular scaffolds (BVS) in swine with and without diabetes mellitus fed a 'fast-food' diet (FF-DM and FF-NDM, respectively) by sequential optical coherence tomography (OCT)-imaging and histology.Fifteen male swine were evaluated. Eight received streptozotocin-injection to induce DM. After 9 months (M), 32 single BVS were implanted in epicardial arteries with a stent to artery (S/A)-ratio of 1.1:1 under quantitative coronary angiography (QCA) and OCT guidance. Lumen, scaffold, neointimal coverage and composition were assessed by QCA, OCT and near-infrared spectroscopy (NIRS) pre- and/or post-procedure, at 3M and 6M. Additionally, polarization-sensitive (PS)-OCT was performed in 7 swine at 6M. After sacrifice at 3M and 6M, histology and polymer degradation analysis were performed.Late lumen loss was high (~60%) within the first 3M after BVS-implantation (P0.20). Neointimal coverage was highly heterogeneous in all swine (DM vs. NDM P>0.05), with focal lipid accumulation, irregular collagen distribution and neointimal calcification. Likewise, polymer mass loss was low (~2% at 3M, ~5% at 6M;P>0.20) and not associated with DM or inflammation.Scaffold coverage showed signs of neo-atherosclerosis in all FF-DM and FF-NDM swine, scaffold polymer was preserved and the vascular response to BVS was not influenced by diabetes.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC5595285?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0183419
URL الوصول: https://doaj.org/article/605cf802360c459c8b9d60499e4f8e7a
رقم الأكسشن: edsdoj.605cf802360c459c8b9d60499e4f8e7a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0183419