دورية أكاديمية
أعرض في EDS

Tumor-Associated Macrophages as Multifaceted Regulators of Breast Tumor Growth

التفاصيل البيبلوغرافية
العنوان: Tumor-Associated Macrophages as Multifaceted Regulators of Breast Tumor Growth
المؤلفون: Maliha Tabassum Munir, Matthew K. Kay, Min H. Kang, Md Mizanur Rahman, Ahmed Al-Harrasi, Mahua Choudhury, Naima Moustaid-Moussa, Fazle Hussain, Shaikh Mizanoor Rahman
المصدر: International Journal of Molecular Sciences, Vol 22, Iss 12, p 6526 (2021)
بيانات النشر: MDPI AG, 2021.
سنة النشر: 2021
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: tumor-associated macrophages, breast cancer, tumor microenvironment, macrophage polarization, immunosuppression, angiogenesis, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Breast cancer is the most commonly occurring cancer in women of Western countries and is the leading cause of cancer-related mortality. The breast tumor microenvironment contains immune cells, fibroblasts, adipocytes, mesenchymal stem cells, and extracellular matrix. Among these cells, macrophages or tumor-associated macrophages (TAMs) are the major components of the breast cancer microenvironment. TAMs facilitate metastasis of the breast tumor and are responsible for poor clinical outcomes. High TAM density was also found liable for the poor prognosis of breast cancer. These observations make altering TAM function a potential therapeutic target to treat breast cancer. The present review summarizes the origin of TAMs, mechanisms of macrophage recruitment and polarization in the tumor, and the contributions of TAMs in tumor progression. We have also discussed our current knowledge about TAM-targeted therapies and the roles of miRNAs and exosomes in re-educating TAM function.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/22/12/6526; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms22126526
URL الوصول: https://doaj.org/article/d60a6059f01e413c935a47310a242738
رقم الأكسشن: edsdoj.60a6059f01e413c935a47310a242738
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms22126526