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أعرض في EDS

Multi-center study on mortality in children, and adults with sickle cell anemia-risk factors and causes of death

التفاصيل البيبلوغرافية
العنوان: Multi-center study on mortality in children, and adults with sickle cell anemia-risk factors and causes of death
المؤلفون: Salam Alkindi, Salma Al-Jadidi, Safa Al-Adawi, Refaat Abdullah Elsadek, Ali Al Madhani, Maryam Al-Nabhani, Anil V. Pathare
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Sickle cell disease, Predictors of mortality, Acute chest syndrome, Sepsis, Sudden death, SCD, Medicine, Science
الوصف: Abstract Sickle cell disease (SCD) is a major public health burden worldwide with increasing morbidity and mortality. The study evaluates the risk factors associated with mortality in SCD patients, between the years 2006 and 2020 at three hospitals in Oman. The analysis includes clinical manifestations, haematological, biochemical, and radiological parameters, use of antibiotics, and blood and exchange transfusions. Our cohort included 123 patients (82 males, 41 females), with a median age of 27 (Interquartile Range 21–35 years). SCD related complications included acute chest syndrome (ACS) in 52.8%, splenic sequestration in 21.1%, right upper quadrant syndrome in 19.5%, more than > 6 VOC/year in 17.9%, and stroke in 13.8%. At the terminal admission, patients had cough, reduced O2 saturation, crepitation and fever in 24.4%, 49.6%, 53.6% and 68.3% respectively. Abnormal chest X-ray and chest CT scan were seen in 57.7%, and 76.4% respectively. Laboratory parameters showed a significant drop in hemoglobin (Hb) and platelet counts from baseline, with a significant rise in WBC, LDH and CRP from baseline (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-024-58328-9
URL الوصول: https://doaj.org/article/60ee325b232941d6a225a1372d4a724b
رقم الأكسشن: edsdoj.60ee325b232941d6a225a1372d4a724b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-024-58328-9