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Epigenome-wide DNA methylation profiling of portal vein tumor thrombosis (PVTT) tissues in hepatocellular carcinoma patients

التفاصيل البيبلوغرافية
العنوان: Epigenome-wide DNA methylation profiling of portal vein tumor thrombosis (PVTT) tissues in hepatocellular carcinoma patients
المؤلفون: Xiaoxiao Fan, Yirun Li, Xin Yi, Guoqiao Chen, Shengxi Jin, Yili Dai, Bin Cui, Binghua Dai, Hui Lin, Daizhan Zhou
المصدر: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 11, Pp 630-643 (2020)
بيانات النشر: Elsevier, 2020.
سنة النشر: 2020
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Aberrant methylation is a hallmark of hepatocellular carcinoma and plays an important role in tumor initiation and progression. However, the epigenome-wide methylation patterns of portal vein tumor thrombosis (PVTTs) have not been fully explored. Here, we performed epigenome-wide DNA methylation of adjacent normal tissues (ANTs), paired tumor tissues and paired PVTTs using an Infinium HumanMethylation450 array (n = 11) and conducted the Sequenom EpiTYPER assays to confirm the aberrantly methylated genes. MTS and apoptosis assay were used to assess the synergistic effect of two drugs on the HCC cell lines. We found the mean global methylation levels of HCC tissues and PVTTs were significantly lower than ANTs (P 10%, P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1476-5586
Relation: http://www.sciencedirect.com/science/article/pii/S1476558620301536; https://doaj.org/toc/1476-5586
DOI: 10.1016/j.neo.2020.09.007
URL الوصول: https://doaj.org/article/6105fecc2dbb42ffa593a5b21656e985
رقم الأكسشن: edsdoj.6105fecc2dbb42ffa593a5b21656e985
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14765586
DOI:10.1016/j.neo.2020.09.007