دورية أكاديمية
κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway
| العنوان: | κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway |
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| المؤلفون: | Shi Yi, Tao Huaqiang, Li Xueyan, Zhang Liyuan, Li Chunhui, Sun Wen, Chu Miao, Chen Kai, Zhu Pengfei, Wang Qiang, Gu Chengyong, Wang Liangliang, Yang Xing, Hao Yuefeng |
| المصدر: | Acta Biochimica et Biophysica Sinica, Vol 56, Pp 82-95 (2023) |
| بيانات النشر: | China Science Publishing & Media Ltd., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biochemistry LCC:Genetics |
| مصطلحات موضوعية: | synovial inflammation, macrophage polarization, κ-opioid receptor, osteoarthritis, NF-κB, Biochemistry, QD415-436, Genetics, QH426-470 |
| الوصف: | Osteoarthritis (OA) is a prevalent and chronic joint disease that affects the aging population, causing pain and disability. Macrophages in synovium are important mediators of synovial inflammatory activity and pathological joint pain. Previous studies have demonstrated the significant involvement of κ-opioid receptor (KOR) in the regulation of pain and inflammation. Our study reveals a significant reduction in synovial KOR expression among patients and mice with OA. Here, we find that KOR activation effectively inhibits the expressions of the LPS-induced-inflammatory cytokines TNF-α and IL-6 by inhibiting macrophage M1 phenotype. Mechanistically, KOR activation effectively suppresses the proinflammatory factor secretion of macrophages by inhibiting the translocation of NF-κB into the nucleus. Our animal experiments reveal that activation of KOR effectively alleviates knee pain and prevents synovitis progression in OA mice. Consistently, KOR administration suppresses the expressions of M1 macrophage markers and the NF-κB pathway in the synovium of the knee. Collectively, our study suggests that targeting KOR may be a viable strategy for treating OA by inhibiting synovitis and improving joint pain in affected patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1672-9145 |
| Relation: | https://doaj.org/toc/1672-9145 |
| DOI: | 10.3724/abbs.2023223 |
| URL الوصول: | https://doaj.org/article/611fa88370a240b8b72466cf09e91e77 |
| رقم الأكسشن: | edsdoj.611fa88370a240b8b72466cf09e91e77 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16729145 |
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| DOI: | 10.3724/abbs.2023223 |