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أعرض في EDS

Mannitol-Enhanced Delivery of Stem Cells and Their Growth Factors across the Blood–Brain Barrier

التفاصيل البيبلوغرافية
العنوان: Mannitol-Enhanced Delivery of Stem Cells and Their Growth Factors across the Blood–Brain Barrier
المؤلفون: Gabriel S. Gonzales-Portillo, Paul R. Sanberg, Max Franzblau, Chiara Gonzales-Portillo, Theo Diamandis, Meaghan Staples, Cyndy D. Sanberg, Cesar V. Borlongan
المصدر: Cell Transplantation, Vol 23 (2014)
بيانات النشر: SAGE Publishing, 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
مصطلحات موضوعية: Medicine
الوصف: Ischemic brain injury in adults and neonates is a significant clinical problem with limited therapeutic interventions. Currently, clinicians have only tPA available for stroke treatment and hypothermia for cerebral palsy. Owing to the lack of treatment options, there is a need for novel treatments such as stem cell therapy. Various stem cells including cells from embryo, fetus, perinatal, and adult tissues have proved effective in preclinical and small clinical trials. However, a limiting factor in the success of these treatments is the delivery of the cells and their by-products (neurotrophic factors) into the injured brain. We have demonstrated that mannitol, a drug with the potential to transiently open the blood–brain barrier and facilitate the entry of stem cells and trophic factors, as a solution to the delivery problem. The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0963-6897
1555-3892
Relation: https://doaj.org/toc/0963-6897; https://doaj.org/toc/1555-3892
DOI: 10.3727/096368914X678337
URL الوصول: https://doaj.org/article/a61309c4197f45ca8f8ce8214d643510
رقم الأكسشن: edsdoj.61309c4197f45ca8f8ce8214d643510
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:09636897
15553892
DOI:10.3727/096368914X678337