دورية أكاديمية
Mannitol-Enhanced Delivery of Stem Cells and Their Growth Factors across the Blood–Brain Barrier
العنوان: | Mannitol-Enhanced Delivery of Stem Cells and Their Growth Factors across the Blood–Brain Barrier |
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المؤلفون: | Gabriel S. Gonzales-Portillo, Paul R. Sanberg, Max Franzblau, Chiara Gonzales-Portillo, Theo Diamandis, Meaghan Staples, Cyndy D. Sanberg, Cesar V. Borlongan |
المصدر: | Cell Transplantation, Vol 23 (2014) |
بيانات النشر: | SAGE Publishing, 2014. |
سنة النشر: | 2014 |
المجموعة: | LCC:Medicine |
مصطلحات موضوعية: | Medicine |
الوصف: | Ischemic brain injury in adults and neonates is a significant clinical problem with limited therapeutic interventions. Currently, clinicians have only tPA available for stroke treatment and hypothermia for cerebral palsy. Owing to the lack of treatment options, there is a need for novel treatments such as stem cell therapy. Various stem cells including cells from embryo, fetus, perinatal, and adult tissues have proved effective in preclinical and small clinical trials. However, a limiting factor in the success of these treatments is the delivery of the cells and their by-products (neurotrophic factors) into the injured brain. We have demonstrated that mannitol, a drug with the potential to transiently open the blood–brain barrier and facilitate the entry of stem cells and trophic factors, as a solution to the delivery problem. The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 0963-6897 1555-3892 |
Relation: | https://doaj.org/toc/0963-6897; https://doaj.org/toc/1555-3892 |
DOI: | 10.3727/096368914X678337 |
URL الوصول: | https://doaj.org/article/a61309c4197f45ca8f8ce8214d643510 |
رقم الأكسشن: | edsdoj.61309c4197f45ca8f8ce8214d643510 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 09636897 15553892 |
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DOI: | 10.3727/096368914X678337 |