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Atherosclerotic cardiovascular disease risk among Ghanaians: A comparison of the risk assessment tools.

التفاصيل البيبلوغرافية
العنوان: Atherosclerotic cardiovascular disease risk among Ghanaians: A comparison of the risk assessment tools.
المؤلفون: Francis Agyekum, Florence Koryo Akumiah, Samuel Blay Nguah, Lambert Tetteh Appiah, Khushali Ganatra, Yaw Adu-Boakye, Aba Ankomaba Folson, Harold Ayetey, Isaac Kofi Owusu
المصدر: American Journal of Preventive Cardiology, Vol 18, Iss , Pp 100670- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Diseases of the circulatory (Cardiovascular) system
LCC:Public aspects of medicine
مصطلحات موضوعية: ASCVD, Atherosclerotic cardiovascular disease, Risk scores, Cardiovascular risk, Ghana, Diseases of the circulatory (Cardiovascular) system, RC666-701, Public aspects of medicine, RA1-1270
الوصف: Objectives: Risk stratification is a cornerstone for preventing atherosclerotic cardiovascular disease (ASCVD). Ghana has yet to develop a locally derived and validated ASCVD risk model. A critical first step towards this goal is assessing how the commonly available risk models perform in the Ghanaian population. This study compares the agreement and correlation between four ASCVD risk assessment models commonly used in Ghana. Methods: The Ghana Heart Study collected data from four regions in Ghana (Ashanti, Greater Accra, Northern, and Central regions) and excluded people with a self-declared history of ASCVD. The 10-year fatal/non-fatal ASCVD risk of participants aged 40–74 was calculated using mobile-based apps for Pooled Cohort Equation (PCE), laboratory-based WHO/ISH CVD risk, laboratory-based Framingham risk (FRS), and Globorisk, categorizing them as low, intermediate, or high risk. The risk categories were compared using the Kappa statistic and Spearman correlation. Results: A total of 615 participants were included in this analysis (median age 55 [Inter quartile range 46, 64]) years with 365 (59.3 %) females. The WHO/ISH risk score categorized 504 (82.0 %), 58 (9.4 %), and 53 (8.6 %) as low-, intermediate-, and high-risk, respectively. The PCE categorized 345 (56.1 %), 181 (29.4 %), and 89 (14.5 %) as low-, intermediate- and high-risk, respectively. The Globorisk categorized 236 (38.4 %), 273 (44.4 %), and 106 (17.2 %) as low-, intermediate-, and high-risk, respectively. Significant differences in the risk categorization by region of residence and age group were noted. There was substantial agreement between the PCE vs FRS (Kappa = 0.8, 95 % CI 0.7 – 0.8), PCE vs Globorisk (Kappa = 0.6; 95 % CI 0.6 – 0.7), and FRS vs Globorisk (Kappa = 0.6; 95 % CI 0.6 – 0.7). However, there was only fair agreement between the WHO vs Globorisk (Kappa = 0.3; 95 % CI 0.3–0.4) and moderate agreement between the WHO vs PCE and WHO vs FRS. Conclusion: There are significant differences in the ASCVD risk prediction tools in the Ghanaian population, posing a threat to primary prevention. Therefore, there is a need for locally derived and validated tools.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2666-6677
Relation: http://www.sciencedirect.com/science/article/pii/S2666667724000382; https://doaj.org/toc/2666-6677
DOI: 10.1016/j.ajpc.2024.100670
URL الوصول: https://doaj.org/article/e61336ff3bd84e07b0e9b5a11042495f
رقم الأكسشن: edsdoj.61336ff3bd84e07b0e9b5a11042495f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:26666677
DOI:10.1016/j.ajpc.2024.100670