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Incidence, Remission and Mortality of Convulsive Epilepsy in Rural Northeast South Africa.

التفاصيل البيبلوغرافية
العنوان: Incidence, Remission and Mortality of Convulsive Epilepsy in Rural Northeast South Africa.
المؤلفون: Ryan G Wagner, Christian Bottomley, Anthony K Ngugi, Fredrick Ibinda, F Xavier Gómez-Olivé, Kathleen Kahn, Stephen Tollman, Charles R Newton, SEEDS Writing Group, Ryan Wagner, Rhian Twine, Myles Connor, Mark Collinson, Honratio Masanja, Alexander Mathew, Angelina Kakooza, George Pariyo, Stefan Peterson, Donald Ndyo-mughenyi, Rachael Odhiambo, Eddie Chengo, Martin Chabi, Evasius Bauni, Gathoni Kamuyu, Victor Mung'ala Odera, James O Mageto, Ken Ae-Ngibise, Bright Akpalu, Albert Akpalu, Francis Agbokey, Patrick Adjei, Seth Owusu-Agyei, Immo Kleinschmidt, Victor C K Doku, Peter Odermatt, Brian Neville, Josemir W Sander, Steve White, Thomas Nutman, Patricia Wilkins, John Noh
المصدر: PLoS ONE, Vol 10, Iss 6, p e0129097 (2015)
بيانات النشر: Public Library of Science (PLoS), 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BackgroundEpilepsy is one of the most common neurological conditions globally, estimated to constitute 0.75% of the global burden of disease, with the majority of this burden found in low- and middle- income countries (LMICs). Few studies from LMICs, including much of sub-Saharan Africa, have described the incidence, remission or mortality rates due to epilepsy, which are needed to quantify the burden and inform policy. This study investigates the epidemiological parameters of convulsive epilepsy within a context of high HIV prevalence and an emerging burden of cardiovascular disease.MethodsA cross-sectional population survey of 82,818 individuals, in the Agincourt Health and Socio-demographic Surveillance Site (HDSS) in rural northeast South Africa was conducted in 2008, from which 296 people were identified with active convulsive epilepsy. A follow-up survey was conducted in 2012. Incidence and mortality rates were estimated, with duration and remission rates calculated using the DISMOD II software package.ResultsThe crude incidence for convulsive epilepsy was 17.4/100,000 per year (95%CI: 13.1-23.0). Remission was 4.6% and 3.9% per year for males and females, respectively. The standardized mortality ratio was 2.6 (95%CI: 1.7-3.5), with 33.3% of deaths directly related to epilepsy. Mortality was higher in men than women (adjusted rate ratio (aRR) 2.6 (95%CI: 1.2-5.4)), and was significantly associated with older ages (50+ years versus those 0-5 years old (RR 4.8 (95%CI: 0.6-36.4)).ConclusionsThe crude incidence was lower whilst mortality rates were similar to other African studies; however, this study found higher mortality amongst older males. Efforts aimed at further understanding what causes epilepsy in older people and developing interventions to reduce prolonged seizures are likely to reduce the overall burden of ACE in rural South Africa.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0129097
URL الوصول: https://doaj.org/article/c61674a552914cceb7507238c13614b0
رقم الأكسشن: edsdoj.61674a552914cceb7507238c13614b0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0129097