دورية أكاديمية
Ointment formulation of snakehead fish (Channa striata) Extract with variations of CMC-Na and carbopol
| العنوان: | Ointment formulation of snakehead fish (Channa striata) Extract with variations of CMC-Na and carbopol |
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| المؤلفون: | Mohamad Andrie, Wintari Taurina |
| المصدر: | Pharmaciana, Vol 11, Iss 1, Pp 101-108 (2021) |
| بيانات النشر: | Universitas Ahmad Dahlan, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | snakehead fish extract, kelulut honey, cmc-na, carbopol, Pharmacy and materia medica, RS1-441 |
| الوصف: | Snakehead fish (Channa striata) and kelulut honey (Trigona sp.) have the potential to accelerate the wound-healing process. These natural ingredients are formulated in the form of ointment because ointment is an external medicine that is easy to apply and has long contact with the skin. Previous research has shown that the snakehead fish extract ointment undergoes phase separation, so it needs a material that can bind the snakehead fish extract and kelulut honey as the active substances in the preparation. This study aimed to determine the effect of variations in the concentration of CMC-Na (3%, 4.5%, 6%) and Carbopol (0.5%, 1%, 2%) as a binder on the ointment physical properties and to determine the best snakehead fish (Channa striata) extract ointment formulation. The ointment of snakehead fish extract was tested for organoleptic, homogeneity, spreadability, and adhesion. The test results were analyzed by One Way ANOVA with a confidence level of 95%. The results showed that the higher the concentrations of CMC-Na and Carbopol used, the greater the adhesive power and the lower the spreadability. Ointment with Carbopol has a wider spreadability and a softer consistency than ointment with CMC-Na. The best formulation is shown by the Carbopol 0.5% (F4) formula, where the average spreadability with a load of 150 g is 5.09 cm and the average adhesion is 229 seconds. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2088-4559 2477-0256 |
| Relation: | http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/18385/pdf_183; https://doaj.org/toc/2088-4559; https://doaj.org/toc/2477-0256 |
| DOI: | 10.12928/pharmaciana.v11i1.18385 |
| URL الوصول: | https://doaj.org/article/61c2f2860f82451a9fe2e25662edff91 |
| رقم الأكسشن: | edsdoj.61c2f2860f82451a9fe2e25662edff91 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20884559 24770256 |
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| DOI: | 10.12928/pharmaciana.v11i1.18385 |