دورية أكاديمية
Association between prenatal exposure to alkylphenols and intelligence quotient among preschool children: sex-specific effects
| العنوان: | Association between prenatal exposure to alkylphenols and intelligence quotient among preschool children: sex-specific effects |
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| المؤلفون: | Jinghua Long, Jun Liang, Tao Liu, Huishen Huang, Jiehua Chen, Qian Liao, Lixiang Pang, Kaiqi Yang, Manlin Chen, Qian Chen, Xiaorong Huang, Qihua Zhu, Xiaoyun Zeng, Dongping Huang, Xiaoqiang Qiu |
| المصدر: | Environmental Health, Vol 23, Iss 1, Pp 1-14 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Industrial medicine. Industrial hygiene LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Alkylphenols, Prenatal, Intelligence quotient, Preschool children, Sex-specificity, Industrial medicine. Industrial hygiene, RC963-969, Public aspects of medicine, RA1-1270 |
| الوصف: | Abstract Background While prenatal exposure to alkylphenols (APs) has been demonstrated to be associated with neurodevelopmental impairments in animals, the evidence from epidemiological studies remains limited and inconclusive. This study aimed to explore the link between AP exposure during pregnancy and the intelligence quotient (IQ) of preschool children. Methods A total of 221 mother-child pairs from the Guangxi Zhuang Birth Cohort were recruited. Nonylphenol (NP), 4-tert-octylphenol (4-T-OP), 4-n-nonylphenol (4-N-NP), and 4-n-octylphenol were measured in maternal serum in early pregnancy. Childhood IQ was evaluated by the Fourth Edition of Wechsler Preschool and Primary Scale of the Intelligence at 3 to 6 years of age. The impact of APs on childhood IQ were evaluated by generalized linear models (GLMs), restricted cubic spline (RCS), and Bayesian kernel machine regression (BKMR). Results In GLMs, prenatal exposure to NP and the second tertile of 4-T-OP exhibited an inverse association with full-scale IQ (FSIQ) (β = -2.38; 95% CI: -4.59, -0.16) and working memory index (WMI) (β = -5.24; 95% CI: -9.58, -0.89), respectively. Prenatal exposure to the third tertile of 4-N-NP showed a positive association with the fluid reasoning index (β = 4.95; 95% CI: 1.14, 8.77) in total children, as well as in girls when stratified by sex. A U-shaped relationship between maternal 4-T-OP and WMI was noted in total children and girls by RCS (all P nonlinear |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1476-069X |
| Relation: | https://doaj.org/toc/1476-069X |
| DOI: | 10.1186/s12940-024-01047-5 |
| URL الوصول: | https://doaj.org/article/a61c6ae6e9684a86b9e82b4d97abaf73 |
| رقم الأكسشن: | edsdoj.61c6ae6e9684a86b9e82b4d97abaf73 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1476069X |
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| DOI: | 10.1186/s12940-024-01047-5 |